in progress

Draft Recommendation Statement

Screening and Interventions to Prevent Dental Caries in Children Younger Than Age 5 Years:

May 11, 2021

Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.

This topic is being updated. Please use the link(s) below to see the latest documents available.
  • Update in Progress for Screening and Interventions to Prevent Dental Caries in Children Younger Than Age 5 Years:

Recommendation Summary

Population Recommendation Grade
Children younger than age 5 years The USPSTF recommends that primary care clinicians prescribe oral fluoride supplementation starting at age 6 months for children whose water supply is deficient in fluoride. B
Children younger than age 5 years The USPSTF recommends that primary care clinicians apply fluoride varnish to the primary teeth of all infants and children starting at the age of primary tooth eruption. B
Children younger than age 5 years The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of routine screening examinations for dental caries performed by primary care clinicians in children younger than age 5 years. I

Additional Information

Tools
Related Resources
  • Screening and Interventions to Prevent Dental Caries in Children Younger Than Age 5 Years (Consumer Guide): Draft Recommendation | Link to File

Full Recommendation:

Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.

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Dental caries is the most common chronic disease in children in the United States.1-3 According to the 2011–2016 National Health and Nutrition Examination Survey, approximately 23% of children ages 2 to 5 years have dental caries in their primary teeth.4 Prevalence is higher in Mexican American children (33%) and non-Hispanic Black children (28%) compared with non-Hispanic White children (18%).5 Dental caries in early childhood is associated with pain, loss of teeth, impaired growth, decreased weight gain, negative effects on quality of life, poor school performance, and future dental caries.1

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The USPSTF concludes with moderate certainty that there is a moderate net benefit of preventing future dental caries with oral fluoride supplementation at recommended doses in children older than age 6 months whose water supply is deficient in fluoride.

The USPSTF concludes with moderate certainty that there is a moderate net benefit of preventing future dental caries with fluoride varnish application in all children younger than age 5 years.

The USPSTF concludes that the evidence is insufficient on performing routine oral screening examinations for dental caries by primary care clinicians in children younger than age 5 years, and the balance of benefits and harms of screening cannot be determined.

See the Table for more information on the USPSTF recommendation rationale and assessment. For more details on the methods the USPSTF uses to determine the net benefit, see the USPSTF Procedure Manual6.

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Patient Population Under Consideration

This recommendation applies to asymptomatic children younger than age 5 years.

Assessment of Risk

All children are at potential risk for dental caries. There are no validated screening tools to determine which children are at higher risk for dental caries; however, there are a number of individual factors that elevate risk. Higher prevalence and severity of dental caries are found among low-income and racial/ethnic (e.g., Black and Mexican American) populations.1 Risk factors for dental caries in children are multifactorial. Biological risk factors include cariogenic bacteria, developmental defects of tooth enamel, and low saliva flow rates. Social determinants of health (nonbiological factors) that are associated with increased caries risk include access to dental care, low socioeconomic status, personal and family oral health history, dietary habits, fluoride exposure, and oral hygiene practices.1,7,8

Interventions to Prevent Dental Caries

Oral fluoride supplementation prevents dental caries in patients with deficient water fluoridation (<0.6 parts fluoride per million parts water [ppm F]).9-11 Topical fluoride is applied as a varnish with a small brush in young children (typically available as 5% sodium fluoride [2.26% F]). Its use for prevention of caries is off-label.12-15

Additional Tools and Resources

There are several related tools and resources that may help clinicians implement this recommendation:

  • The Community Preventive Services Task Force recommends fluoridation of community water sources to reduce dental caries.16
  • The Community Preventive Services Task Force recommends school-based dental sealant delivery programs to prevent caries.17

Suggestions for Practice Regarding the I Statement

In deciding whether to routinely perform screening examinations for dental caries in children from birth to age 5 years, clinicians should consider the following.

Potential Preventable Burden

Dental caries are a common chronic disease that can cause pain and diminished quality of life.4 According to the National Health and Nutrition Examination Survey, the prevalence of dental caries increased from 24% to 28% between 1988–1994 and 1999–2004; the prevalence fell to approximately 23% from 2011 to 2016.5 Seventeen percent of children below the poverty threshold had untreated caries in 2011 to 2014. Dental-related concerns lead to the loss of more than 50 million school hours each year.3

Potential Harms

Primary care screening examinations for dental caries in children from birth to age 5 years are noninvasive and not likely to cause serious harms.

Current Practice

A 2009 study demonstrated that only about half of pediatricians reported examining the teeth of half of their patients ages 0 to 3 years and few (4%) reported regularly applying fluoride varnish.18

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Scope of Review

The USPSTF commissioned a systematic review1 to update its 2014 recommendation on screening and interventions to prevent dental caries in children younger than age 5 years. The review focused on screening for caries, assessment of risk for future caries, and the effectiveness of various interventions (e.g., caregiver/guardian oral health education, preventive medication, or referral to a dentist) that have possible benefits in preventing caries. The USPSTF limited its consideration of caries screening and prevention by primary care clinicians to infants and preschool-aged children. The rationale for this decision was that primary care clinicians are more likely than dentists to have contact with children younger than age 5 years in the United States; this situation changes as children reach school age and beyond as opportunities to provide dental services in school settings become available. In addition, as children grow older, dental professionals use sealants rather than fluoride varnish. As such, the USPSTF limited its review of the evidence of preventive interventions for dental caries to this age group. This recommendation should not be construed to imply that preventive interventions for dental caries should cease after age 5 years.

Accuracy of Screening

One good-quality cohort study (n=258) in children younger than age 36 months found that a primary care pediatrician examination following 2 hours of training was associated with a sensitivity of 0.76 and specificity of 0.95 for identifying a child with one or more cavities, a sensitivity of 0.49 and specificity of 0.99 for identifying a tooth with a cavity, and a sensitivity of 0.63 and specificity of 0.98 for identifying children in need of a dental referral, compared with a pediatric dentist evaluation.1 A fair-quality study in 110 children ages 18 to 36 months found that an oral examination by a pediatrician had a sensitivity of 1.0 and a specificity of 0.87 for identifying nursing caries.1

One fair-quality study (n=1,681) found that a novel caries risk assessment tool administered by health visitor nurses in children age 1 year was associated with sensitivity of 0.53 and specificity of 0.77 for predicting any dentin lesions at age 4 years and sensitivity of 0.65 and specificity of 0.69 for predicting presence of three or more dentin lesions.1

Effectiveness of Screening

No studies compared clinical outcomes between children younger than age 5 years who were screened and not screened for dental caries by primary care clinicians.

Harms of Screening

No studies reported harms of screening in children younger than age 5 years who were screened and not screened by for dental caries primary care clinicians.

Effectiveness of Preventive Interventions

The USPSTF considered 13 trials (two of good quality and the rest fair quality). The number of participants ranged from 123 to 2,536 (total n=7,982). Trials were conducted in the United States, Europe, Brazil, China, and Iran, and two trials in Aboriginal communities in Australia and Canada. The mean age of enrolled children was 1 year to younger than 2 years in six trials and 2 years to younger than 5 years in seven trials; one trial did not report mean age but enrolled children ages 6 months to 5 years.1 Three trials were conducted in preschool or daycare settings and the others were conducted in clinics. Twelve trials evaluated children classified as higher risk, based on low socioeconomic status, high community prevalence of caries, high baseline caries burden, or low rates of oral health behaviors (e.g., tooth brushing with fluoride toothpaste).1

The USPSTF found no studies that directly evaluated referral by a primary care clinician to a dentist on caries incidence. One fair-quality, retrospective cohort study (n=19,888) and one fair-quality, observational study (n=11,394) of children enrolled in Medicaid found no difference in rates of subsequent dental procedures between earlier and later first preventive dental visits among children with no caries at baseline.1 Four fair-quality, observational studies (n=61,194) of children enrolled in Medicaid found that patients receiving a preventive dental visit were more likely to receive subsequent caries treatment than patients who saw a primary care provider. However, the results are subject to confounding because children who saw a dentist might have had a greater indication for dental services. The studies were also not designed to determine the referral source or effects of dental referral from primary care vs. no referral.1

The USPSTF found limited evidence on educational or counseling interventions. One new fair-quality trial (n=104) found that oral health education for mothers of caries-free children ages 12 to 36 months was associated with reduced risk of incident dental caries vs. usual care at 6 months (13.5% vs. 34.7%; risk ratio [RR], 0.39 [95% CI, 0.18 to 0.85]).1

One randomized trial and four nonrandomized trials compared dietary fluoride supplementation with no supplementation in settings with a water fluoride level less than 0.6 ppm F and found decreased caries incidence. The percentage reduction in incidence ranged from 48% to 72% for primary teeth and 51% to 81% for primary tooth surfaces.1

The USPSTF found 13 trials (n=7982) that demonstrated that topical fluoride was associated with decreased caries increment (11 trials; N=4,308; mean difference, -1.19 [95% CI, -2.16 to -0.42]; I2=87%) and decreased likelihood of incident caries (10 trials; N=6,752; RR, 0.79 [95% CI, 0.62 to 0.99]; I2=83%; absolute risk difference, -7% [95% CI, -14% to -1%]) vs. placebo or no varnish. The majority of the trials were conducted in higher-risk populations or settings.1 “High risk” was defined by low socioeconomic status, high caries burden, or suboptimal oral health practices (e.g., inadequate tooth brushing). There was no difference in benefits of topical fluoride related to whether trials were conducted in settings with adequate fluoridation.1 Evidence on other preventive interventions was limited (i.e., xylitol and silver diamine fluoride).1

Harms of Preventive Interventions

Nineteen observational studies showed an association between ingestion of systemic fluoride in early childhood and enamel fluorosis of permanent teeth.1 Four trials (n=4,141) found no differences in risk of fluorosis or any other adverse event between fluoride varnish and placebo or no varnish.1

How Does Evidence Fit With Biological Understanding?

Systemic fluoride becomes incorporated into tooth structures during their formation. If fluoride is ingested repeatedly during tooth development, it is deposited throughout the tooth surface and provides protection against caries. Topical fluoride treatments, such as varnishes, help protect teeth that are already present. In this method, fluoride is incorporated into the surface layer of the teeth, making them more resistant to decay. Systemic fluoride also provides some measure of topical effects, as it is found in the saliva and bathes the teeth. Thus, providing both systemic and topical fluoride to children during tooth development fits with the biologic understanding of fluoride's protective actions against dental decay. All children with erupted teeth can potentially benefit from the periodic application of fluoride varnish, regardless of the levels of fluoride in their water. Although the evidence to support fluoride varnish is drawn from higher-risk populations, the provision of fluoride varnish to all children is reasonable since the prevalence of risk factors is high in the U.S. population.20-22

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More studies are needed that address the following.

  • Research is needed to validate the accuracy and utility of caries risk assessment instruments for use in primary care settings, and to determine how referral of young children for dental care by primary care clinicians affects caries outcomes.
  • Further research would also be helpful to confirm the benefits of fluoride varnish among lower-risk children.
  • Future studies on risk assessment and preventive interventions should enroll sufficient numbers from racial/ethnic populations to understand the benefits and harms of interventions in these specific groups. Research is needed to identify effective oral health educational and counseling interventions for parents and caregivers/guardians of young children. Studies are also needed on the benefits and harms of silver diamine fluoride for the prevention of caries in young children.
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The American Academy of Pediatrics recommends a first dental visit by age 1 year. It also recommends dietary fluoride supplements for all children who do not have an adequate supply of fluoride in their primary drinking water.23

The American Dental Association recommends that children be seen by a dentist within 6 months of eruption of the first tooth and no later than age 12 months. It also recommends 2.26% fluoride varnish for children younger than age 6 years who are at risk for developing dental caries.24

The Centers for Disease Control and Prevention recommend that fluoride supplements may be best prescribed to children at high risk for dental caries whose drinking water lacks adequate fluoridation.21

The American Academy of Pediatric Dentistry states that fluoride dietary supplements should be considered for children at risk for caries who drink fluoride-deficient (<0.6 ppm F) water. It also states that children at increased risk for caries should receive a professional fluoride treatment (e.g., 5% sodium fluoride varnish or 1.23% acidulated phosphate fluoride) every 6 months.25

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1. Chou R, Pappas M, Dana T, Selph S, Hart E, Schwarz E. Screening and Prevention of Dental Caries in Children Younger Than Five Years of Age: A Systematic Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 2102. AHRQ Publication No. 21-05279-EF-1. Rockville, MD: Agency for Healthcare Research and Quality; 2021.
2. National Center for Health Statistics. Healthy People 2010: Final Review. Published 2012. Accessed April 27, 2021. https://www.cdc.gov/nchs/data/hpdata2010/hp2010_final_review.pdf
3. U.S. Department of Health and Human Services. Oral Health in America: A Report of the Surgeon General. Published 2000. Accessed April 27, 2021. https://www.nidcr.nih.gov/sites/default/files/2017-10/hck1ocv.%40www.surgeon.fullrpt.pdf
4. Centers for Disease Control and Prevention. Oral Health Surveillance Report: Trends in Dental Caries and Sealants, Tooth Retention, and Edentulism, United States, 1999–2004 to 2011–2016. Atlanta: Centers for Disease Control and Prevention; 2019.
5. Dye BA, Mitnik GL, Iafolla TJ, Vargas CM. Trends in dental caries in children and adolescents according to poverty status in the United States from 1999 through 2004 and from 2011 through 2014. J Am Dent Assoc. 2017;148(8):550-565.e7
6. US Preventive Services Task Force. Procedure Manual. https://uspreventiveservicestaskforce.org/uspstf/about-uspstf/methods-and-processes/procedure-manual. Accessed May 4, 2021
7. Caufield PW, Griffen AL. Dental caries. An infectious and transmissible disease. Pediatr Clin North Am. 2000;47(5):1001-1019, v.
8. Tinanoff N, Reisine S. Update on early childhood caries since the Surgeon General's Report. Acad Pediatr. 2009;9(6):396-403.
9. Dooley D, Moultrie NM, Heckman B, et al. Oral health prevention and toddler well-child care: routine integration in a safety net system. Pediatrics. 2016;137(1):e20143532.
10. Institute of Medicine and National Research Council. Improving Access to Oral Health Care for Vulnerable and Underserved Populations. Washington, DC: National Academies Press; 2011.
11. Nicolae A, Levin L, Wong PD, et al. Identification of early childhood caries in primary care settings. Paediatr Child Health. 2018;23(2):111-115.
12. Garcia RI, Gregorich SE, Ramos-Gomez F, et al. Absence of fluoride varnish-related adverse events in caries prevention trials in young children, United States. Prev Chronic Dis. 2017;14:E17.
13. Crystal YO, Marghalani AA, Ureles SD, et al. Use of silver diamine fluoride for dental caries management in children and adolescents, including those with special health care needs. Pediatr Dent. 2017;39(5):135-145.
14. Gao SS, Zhao IS, Hiraishi N, et al. Clinical trials of silver diamine fluoride in arresting caries among children: a systematic review. JDR Clin Trans Res. 2016;1(3):201-210.
15. American Academy of Pediatric Dentistry. Policy on the use of xylitol in pediatric dentistry. Revised 2020. Accessed April 27, 2021. https://www.aapd.org/research/oral-health-policies--recommendations/use-of-xylitol/
16. The Community Guide. Dental Caries (Cavities): Community Water Fluoridation. Published April 2013. Accessed April 27, 2021. https://www.thecommunityguide.org/findings/dental-caries-cavities-community-water-fluoridation
17. The Community Guide. Dental Caries (Cavities): School-Based Dental Sealant Delivery Programs. Published April 2013. Accessed April 27, 2021. https://www.thecommunityguide.org/findings/dental-caries-cavities-school-based-dental-sealant-delivery-programs
18. Lewis CW, Boulter S, Keels MA, et al. Oral health and pediatricians: results of a national survey. Acad Pediatr. 2009;9(6):457-61.
19. Moyer VA; US Preventive Services Task Force. Prevention of dental caries in children from birth through age 5 years: US Preventive Services Task Force recommendation statement. Pediatrics. 2014;133(6):1102-1111.
20. Bader JD, Rozier RG, Lohr KN, Frame PS. Physicians' roles in preventing dental caries in preschool children: a summary of the evidence for the U.S. Preventive Services Task Force. Am J Prev Med. 2004;26(4):315-25.37.
21. Centers for Disease Control and Prevention. Recommendations for using fluoride to prevent and control dental caries in the United States. MMWR Recomm Rep. 2001;50(RR-14):1-42.
22. Hale KJ. Oral health risk assessment timing and establishment of the dental home. Pediatrics. 2003;111(5 Pt 1):1113-6.
23. Clark MB, Slayton RL; Section on Oral Health. Fluoride use in caries prevention in the primary care setting. Pediatrics. 2014;134(3):626-633.
24. Maguire A. ADA clinical recommendations on topical fluoride for caries prevention. Evid Based Dent. 2014;15(2):38-39.
25. American Academy of Pediatric Dentistry. Guideline on Fluoride Therapy. Revised 2018. Accessed April 28, 2021. http://www.aapd.org/media/Policies_Guidelines/G_fluoridetherapy.pdf

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Rationale Assessment
Detection There is inadequate evidence about the accuracy of screening performed by a primary care clinician in identifying children younger than age 5 years who have caries lesions or are at increased risk for future dental caries.
Benefits of early detection and preventive interventions
  • There is inadequate evidence on the effectiveness of oral screening (including risk assessment) performed by a primary care clinician in preventing dental caries in children younger than age 5 years.
  • There is adequate evidence that dietary fluoride supplementation in children who have low levels of fluoride in their water can provide moderate benefit in preventing dental caries.
  • There is adequate evidence that application of fluoride varnish to the primary teeth of all children can provide moderate benefit in preventing dental caries.
Harms of early detection and preventive interventions
  • There is inadequate evidence to assess the harms of oral health screening performed by a primary care clinician in children younger than age 5 years.
  • There is adequate evidence to bound the harms for dietary fluoride supplementation and topical fluoride application as no greater than small, based on limited evidence of harms.
USPSTF Assessment
  • The USPSTF concludes with moderate certainty that there is a moderate net benefit of preventing future dental caries with oral fluoride supplementation at recommended doses in children older than age 6 months whose water supply is deficient in fluoride.
  • The USPSTF concludes with moderate certainty that there is a moderate net benefit of preventing future dental caries with fluoride varnish application in all children younger than age 5 years.
  • The benefits and harms of oral screening for dental caries by primary care clinicians in children younger than age 5 years are uncertain, and the balance of benefits and harms cannot be determined.
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