Draft Recommendation Statement
Human Immunodeficiency Virus (HIV) Infection: Screening
November 20, 2018
Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.
The U.S. Preventive Services Task Force (USPSTF) makes recommendations about the effectiveness of specific preventive care services for patients without obvious related signs or symptoms.
It bases its recommendations on the evidence of both the benefits and harms of the service and an assessment of the balance. The USPSTF does not consider the costs of providing a service in this assessment.
The USPSTF recognizes that clinical decisions involve more considerations than evidence alone. Clinicians should understand the evidence but individualize decisionmaking to the specific patient or situation. Similarly, the USPSTF notes that policy and coverage decisions involve considerations in addition to the evidence of clinical benefits and harms.
Approximately 1.1 million persons in the United States are currently living with HIV, and more than 700,000 persons have died from AIDS since the first cases were reported in 1981.1 The estimated prevalence of HIV infection among persons age 13 years and older in the United States is 0.4% (0.7% in males and 0.2% in females),2 and data from the Centers for Disease Control and Prevention (CDC) 2016 HIV Surveillance Report show a significant increase in HIV diagnoses starting at age 15 years (compared with ages 13 to 14 years).1 The annual number of new cases of HIV infection reported in the United States has decreased slightly in recent years, from about 42,000 new cases in 2011 to 40,000 in 2016.1 Approximately 15% of persons living with HIV are unaware of their infection.2, 3 It is estimated that persons unaware of their HIV status are responsible for 40% of transmission of HIV in the United States.3
An estimated 8,700 women living with HIV give birth each year in the United States.4 HIV can be transmitted from mother to child during pregnancy, labor, delivery, and breastfeeding. The incidence of perinatal HIV infection in the United States peaked in 1992,5 and has declined significantly following the implementation of routine prenatal HIV screening and the use of effective therapies and precautions to prevent mother-to-child transmission. Nearly 22,000 perinatal infections were prevented between 1994 and 2010 because of screening and preventive measures.6
The USPSTF found convincing evidence that currently recommended HIV tests are highly accurate in diagnosing HIV infection.
Benefits of Detection and Early Treatment
The USPSTF found convincing evidence that identification and early treatment of HIV infection is of substantial benefit in reducing the risk for AIDS-related events or death. The USPSTF found convincing evidence that the use of antiretroviral therapy (ART) is of substantial benefit in decreasing the risk for HIV transmission to uninfected sex partners. The USPSTF also found convincing evidence that identification and treatment of pregnant women living with HIV infection is of substantial benefit in reducing the rate of mother-to-child transmission. The overall magnitude of the benefit of screening for HIV infection in adolescents, adults, and pregnant women is substantial.
Harms of Detection and Early Treatment
The USPSTF found adequate evidence that individual antiretroviral drugs, ART drug classes, and ART combinations are associated with some harms, including neuropsychiatric, renal, and hepatic harms and an increased risk of preterm birth in pregnant women. The overall magnitude of the harms of screening for and treatment of screen-detected HIV infection in adolescents, adults, and pregnant women is small.
The USPSTF concludes with high certainty that the net benefit of screening for HIV infection in adolescents, adults, and pregnant women is substantial.
Patient Population Under Consideration
This recommendation applies to adolescents and adults, and all pregnant persons regardless of age. Based on the age-stratified incidence of HIV infection, the USPSTF recommends screening for HIV infection beginning at age 15 years. Adolescents younger than age 15 years and adults older than age 65 years should be screened if they have risk factors for HIV infection.
Assessment of Risk
Although all adolescents and adults ages 15 to 65 years should be screened, there are a number of risk factors that increase risk. Among adolescents younger than age 15 years and adults older than age 65 years, clinicians should consider the risk factors of their patients, especially those with new sex partners, and offer testing to those at increased risk.
Most (67%) new cases of HIV infection are attributed to male-to-male sexual contact,1 and the estimated prevalence of HIV infection among men who have sex with men is 12%.2 Injection drug use is another important risk factor for HIV infection; it has been estimated that the prevalence of HIV infection among persons who inject drugs is 1.9%.2 In 2016, males age 13 years and older accounted for 81% of new diagnoses of HIV infection.1 Most (83%) of these new cases of HIV infection were attributed to male-to-male sexual contact, while 9% were attributed to heterosexual contact and 8% to injection drug use, male-to-male sexual contact, or both.1 Among females age 13 years and older, 87% of all new cases were attributed to heterosexual contact and 12% to injection drug use.1
Additional risk factors for HIV infection include having anal intercourse without a condom, vaginal intercourse without a condom and with more than one partner whose HIV status is unknown, exchanging sex for drugs or money, having other sexually transmitted infections (STIs) or requesting testing for STIs (including HIV), and having a sex partner who is living with HIV or is in a high-risk category.
The USPSTF recognizes that these risk categories are not mutually exclusive, the degree of risk exists on a continuum, and persons may not be aware of the HIV or risk status of their sex partner or the person with whom they share drug-injection equipment. Patients may also be reluctant to disclose risk factors to clinicians.
Current CDC guidelines recommend testing for HIV infection with an antigen/antibody immunoassay approved by the U.S. Food and Drug Administration that detects HIV-1 and HIV-2 antibodies and HIV-1 p24 antigen, with supplemental testing following a reactive assay to differentiate between HIV-1 and HIV-2 antibodies.7, 8 If supplemental testing for HIV-1/HIV-2 antibodies is nonreactive or indeterminate (or if acute HIV infection or recent exposure is suspected or reported), an HIV-1 nucleic acid test is recommended to differentiate acute HIV-1 infection from a false-positive test result.7, 8
Antigen/antibody tests for HIV are highly accurate, with reported sensitivities of 99.76% to 100% and specificities of 99.50% to 100%, and results can be available in 2 days or less.7 Rapid antigen/antibody tests are also available.8
When using a rapid HIV antibody test (instead of an antigen/antibody test) for screening, positive results should be confirmed. Pregnant women presenting in labor with unknown HIV status should be screened with a rapid HIV antibody test to get results as soon as possible.
The USPSTF found insufficient evidence to determine appropriate or optimal time intervals or strategies for repeat HIV screening. Repeat testing is reasonable for persons known to be at increased risk for HIV infection, such as sexually active men who have sex with men, persons who have a sex partner living with HIV, or persons who engage in behaviors that may convey an increased risk of HIV infection, such as injection drug use, commercial sex work, or having one or more new (i.e., since a prior HIV test) sex partners of unknown HIV status. The CDC recommends annual screening in persons at increased risk,9 but recognizes that clinicians may wish to screen more frequently (e.g., every 3 or 6 months) depending on the patient’s risk factors, local HIV prevalence, and local policies.10
The USPSTF found no evidence on the yield of repeat prenatal HIV screening compared with one-time screening during a single pregnancy. The CDC9 and the American College of Obstetricians and Gynecologists (ACOG)11 recommend repeat prenatal HIV screening during the third trimester of pregnancy in women with risk factors for HIV acquisition and in women in high-incidence settings, and the CDC notes that repeat HIV screening during the third trimester in all women who test negative early in pregnancy may be considered. Women screened during a previous pregnancy should be rescreened in subsequent pregnancies.
No cure or vaccine for HIV infection currently exists. However, early initiation of ART and other interventions effectively reduce the risk of clinical progression to AIDS, AIDS-defining clinical events, and mortality. Interventions other than ART include prophylaxis for opportunistic infections when clinically indicated, immunizations, and cancer screening. Additionally, treatment of pregnant women living with HIV with ART and other precautions substantially decrease the risk of transmission to the fetus, newborn, or infant.
The clinical treatment of HIV infection is a dynamic scientific field. The U.S. Department of Health and Human Services’ Panel on Antiretroviral Guidelines for Adults and Adolescents regularly updates guidelines for HIV treatment regimens.12
Additional Approaches to Prevention
The USPSTF recognizes that the most effective strategy for reducing HIV-related morbidity and mortality in the United States is primary prevention, or avoidance of exposure to HIV infection. Avoiding behaviors that may convey an increased risk of HIV infection and consistent use of condoms can decrease the risk for transmission of HIV and other STIs. The USPSTF recommends intensive behavioral counseling for all sexually active adolescents and for adults at increased risk for STIs.13
The Community Preventive Services Task Force has made several recommendations related to the prevention of HIV/AIDS and other STIs.14
Prophylactic intervention with antiretroviral medications, both pre- and post-exposure, can prevent HIV infection. Post-exposure prophylaxis is used in persons who do not have HIV infection and may have been exposed to it via sexual contact, occupational or nonoccupational needlestick or other injury, or sharing injection drug equipment. When initiated soon after possible exposure, post-exposure prophylaxis can prevent HIV infection. Pre-exposure prophylaxis can be used in persons who do not have HIV and are at high risk for acquiring HIV infection. It consists of antiretroviral medication taken every day, before potential exposure. The USPSTF is currently reviewing the evidence for pre-exposure prophylaxis for HIV infection for a separate recommendation statement.
More information about HIV and AIDS is available at HIV.gov15 and from the CDC.16 The CDC has made recommendations on HIV screening in adults, adolescents, and pregnant women in health care settings9 and the prevention of HIV transmission in adults and adolescents living with HIV;17 guidelines on the use of ART are regularly updated at www.aidsinfo.nih.gov.12
As recommended by the CDC, HIV screening should be voluntary and done only with the patient's knowledge and understanding.9 Patients should be informed orally or in writing that HIV testing will be performed unless they decline (opt-out screening). The USPSTF further concurs that before HIV testing, patients should receive an explanation of HIV infection and the meaning of positive and negative test results. Patients should also be offered the opportunity to ask questions and to decline testing.
Research Needs and Gaps
Research is needed on the yield of repeat versus one-time HIV screening and different repeat screening intervals to inform recommendations on optimal screening intervals. Data on optimal rescreening strategies in pregnant women are needed.
Persons who initiate ART tend to continue receiving it for an extended length of time. Thus, continued research on the potential harms of long-term use of ART is an important research need. Further research is also needed to understand the effects of in utero exposure to ART on pregnancy outcomes and long-term effects in exposed children, to optimize selection of ART regimens during pregnancy.
Burden of Disease
Since the first cases of AIDS were reported in 1981, more than 700,000 persons in the United States have died from AIDS.1 The CDC estimates that 1.1 million persons in the United States are currently living with HIV infection, including an estimated 15% who are unaware of their infection.2, 3 The annual number of new HIV infections in the United States has decreased slightly in recent years, from about 42,000 new cases in 2011 to 40,000 in 2016.1 Of new cases of HIV infection in 2016, 81% were among males and 19% among females.1 Groups disproportionately affected by HIV infection in the United States include men who have sex with men, black/African American populations, and Hispanic/Latino populations. For example, the estimated overall prevalence of HIV infection in the United States is 0.4%, while the estimated prevalence among men who have sex with men is 12%.2 From 2011 to 2016, HIV incidence rates increased in adults ages 25 to 29 years, and in American Indian/Alaska Native and Asian populations.1
Perinatal HIV transmission has decreased substantially since peaking in 1992.5 There were an estimated 99 cases of perinatal HIV transmission in 2016,1 and approximately 8,700 women living with HIV give birth each year.4 There are racial/ethnic disparities in rates of perinatal HIV transmission, with more than 5 times greater rates in black/African American women than in white or Hispanic/Latino women.18 Of the approximately 99 cases of perinatal HIV infection in 2016, 65% occurred in black/African American mothers.18
Scope of Review
To update its 2013 recommendation, the USPSTF commissioned a systematic review19 on the benefits and harms of screening for HIV infection in nonpregnant adolescents and adults, the yield of screening for HIV infection at different intervals, the effects of initiating ART in persons living with HIV infection at a higher (i.e., >500 cells/mL3) versus lower CD4 (a type of white blood cell in the immune system) count, and the longer-term harms associated with currently recommended ART regimens. The USPSTF also commissioned a systematic review20 on the benefits (specifically, reducing the risk of mother-to-child transmission of HIV infection) and harms of screening for HIV infection in pregnant women, the yield of repeat HIV screening at different intervals during pregnancy, the effectiveness of currently recommended ART regimens for reducing mother-to-child transmission of HIV infection, and the harms of ART during pregnancy to the mother and infant.
Accuracy of Screening Tests
Currently recommended antigen/antibody tests for HIV are highly accurate, with reported sensitivities of 99.76% to 100% and specificities of 99.50% to 100%.7 Recommended rapid HIV tests have similar sensitivities, and somewhat lower reported specificities of 98.6% to 100%.21
Effectiveness of Early Detection and Treatment
The USPSTF found no randomized clinical trials (RCTs) or observational studies that compared clinical outcomes between adults and adolescents screened and not screened for HIV infection. The USPSTF found no studies that evaluated the yield of repeated HIV screening compared with one-time screening, or that compared the yield of different strategies for repeat screening (e.g., risk-based screening vs. routine repeat testing, or repeat screening at different intervals) in adolescents and adults. The USPSTF also found no studies comparing the yield of one-time versus repeat screening or of different frequencies of screening for HIV infection in pregnancy.
The USPSTF reviewed three RCTs—the HIV Prevention Trials Network (HPTN 052) trial (n=1,763).22, 23 the International Network for Strategic Initiatives in Global HIV Trials Strategic Timing of Antiretroviral Treatment (INSIGHT START or START) trial (n=4,685),24 and the Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-Infected Adults (TEMPRANO ANRS 12136) trial (n=2,056)25—and three large fair-quality cohort studies, ranging in sample size from 3,532 to 55,826 (total n=63,478),26-28 that provided evidence on the benefits of early initiation of ART.
The HPTN 052 study randomized participants to initiation of ART at CD4 counts of 250 cells/mL3 or less or 350 to 500 cells/mL3.22 At a mean followup of 2.1 years, initiation of ART at higher CD4 counts was associated with decreased risk of AIDS-related events (4.5% vs. 7.0%; relative risk [RR], 0.65 [95% CI, 0.44 to 0.95]).23 Effects on other outcomes (including all-cause mortality; AIDS-related mortality; and a composite outcome including death, serious AIDS-related events, and serious non–AIDS-related events, such as bacterial infection or cancer) favored early initiation of ART but were not statistically significant.23 The START study found decreased risk of a composite endpoint of all-cause mortality, serious AIDS-related events, and serious non–AIDS-related events,24 and TEMPRANO ANRS found decreased risk of a composite endpoint of all-cause mortality, progression to AIDS, AIDS-defining cancer, and non–AIDS-defining invasive bacterial disease25 in participants treated with immediate ART at CD4 counts greater than 500 cells/mL3 compared with delayed treatment at lower CD4 counts.
The three cohort studies also provide evidence of benefits to early initiation of ART.26-28 Seven-year followup from the HIV Cohorts Analyzed Using Structural Approaches to Longitudinal (HIV CAUSAL) Collaboration showed that ART initiation at CD4 counts greater than 500 cells/mL3 was associated with decreased risk of all-cause mortality and a composite endpoint of progression to AIDS or death compared with initiation at CD4 counts less than 350 cells/mL3.29 A second cohort study from Canada found that initiation of ART at CD4 counts greater than 500 cells/mL3 was associated with lower probability of mortality and AIDS-related morbidity than initiation at CD4 counts less than 500 cells/mL3 or less than 350 cells/mL3.30 Finally, a U.S.-based cohort study found that compared with initiation of ART within 6 months of CD4 counts decreasing to less than 500 cells/mL3, there were greater risks of 10-year all-cause mortality associated with initiation within 6 months of CD4 counts decreasing to less than 350 cells/mL3 (RR, 1.08 [95% CI, 1.00 to 1.16]) or 200 cells/mL3 (RR, 1.25 [95% CI, 1.08 to 1.44]).31
Early initiation of ART and viral suppression has also been shown to decrease risk of HIV transmission.22 Longer-term followup from the HPTN 052 trial showed that early ART initiation is associated with a reduction in risk of HIV transmission to uninfected partners (RR, 0.07 [95% CI, 0.02 to 0.22], for virologically-linked transmission),32 and the observational Partners of People on ART—A New Evaluation of the Risks (PARTNER) study showed no cases of HIV transmission among serodiscordant couples when the partner living with HIV was treated with ART, during 1.3 years of followup.33
In its discussions about the age at which to begin screening, the USPSTF considered the evidence on the age-stratified incidence of HIV infection. Data from the CDC 2016 HIV Surveillance Report showed a significant increase in HIV diagnoses in the United States starting at age 15 years (compared with ages 13 to 14 years). The USPSTF thus recommends routine HIV screening starting at age 15 years, with screening at a younger age in adolescents with risk factors for HIV infection.1
The USPSTF found no studies that compared rates of mother-to-child transmission of HIV infection between pregnant women screened and not screened for HIV infection. The USPSTF found several cohort studies and RCTs that provided evidence on the effectiveness of ART in decreasing rates of mother-to child transmission of HIV infection in pregnant women living with HIV.20 The cohort studies, all conducted in North America, Europe, or Israel, reported rates of mother-to-child transmission of less than 1.0% to 2.8% among women treated with three-drug ART regimens, compared with 9.1% to as much as 67% in one small cohort study among untreated women.20 The RCTs were conducted in Africa or India (i.e., settings with a lower United Nations Human Development Index than the United States), and compared the effects of a heterogeneous group of prenatal, peripartum, and postpartum ART interventions of varying durations on rates of mother-to-child transmission of HIV infection. Across all studies (both the cohort studies and RCTs), later initiation of ART during pregnancy or treatment with fewer than three antiretroviral medications was associated with greater risk of maternal-to-child transmission of HIV infection.20
Potential Harms of Screening and Treatment
Longer-term use of individual antiretroviral drugs and different ART regimens may be associated with several harms. The USPSTF reviewed several studies that reported on the long-term cardiovascular, neuropsychiatric, hepatic, renal, or bone (fracture) harms associated with the use of various antiretroviral drugs and ART regimens.19
Two good-quality RCTs (duration, 2.8 to 5 years) found no differences in risk of serious cardiovascular or cerebrovascular events between different ART regimens.26, 27 Findings on the cardiovascular harms of the drug abacavir are mixed. A meta-analysis of 26 trials found no association between abacavir use and risk of myocardial infarction,28 but two cohort studies found that abacavir was associated with increased risk (RR, 1.98 [95% CI, 1.72 to 2.29] and odds ratio [OR], 1.50 [95% CI, 1.26 to 1.79]).34, 35
The drug efavirenz has been linked to neuropsychiatric adverse events, including depression and suicidal ideation.36 A systematic review (n=8,466; mean duration, 78 weeks) reported rates of neuropsychiatric adverse events among participants taking efavirenz; 29.6% (95% CI 21.9 to 37.3) experienced events of any grade, 6.1% (95% CI, 4.3% to 7.9%) experienced severe neuropsychiatric adverse events, 3.3% (95% CI, 2.2% to 4.3%) had depression, and 0.6% (95% CI, 0.2% to 1.1%) had suicidal ideation.37 However, an analysis of the D:A:D (Data Collection on Adverse Events of Anti-HIV Drugs) study, a large (n >49,000) international study of 11 prospective cohorts from Europe, Australia, and the United States, found no association between use of efavirenz and death from suicide,38 and an analysis of a large (n=19,983) U.S. administrative cohort found no association between initiation of efavirenz and increased risk of suicidal ideation.39
An analysis of the D:A:D cohorts found that tenofovir disoproxil fumarate (TDF) (relative rate, 1.46 [95% CI, 1.11 to 1.93]) and fosamprenavir (relative rate, 1.47 [95% CI, 1.01 to 2.15]) were associated with increased risk of end-stage liver disease or hepatocellular carcinoma, independent of viral hepatitis status, and that emtricitabine was associated with decreased risk of these outcomes (relative rate, 0.51 [95% CI, 0.32 to 0.83]).40 However, the absolute risk of ART-related liver deaths in the D:A:D cohorts was low (0.04/1,000 person-years).41 Another D:A:D analysis found an association between use of TDF (rate ratio, 1.14 per year of exposure [95% CI, 1.10 to 1.19]) or ritonavir-boosted atazanavir (rate ratio, 1.20 per year of exposure [95% CI, 1.13 to 1.26]) and increased risk of chronic kidney disease.42 A second observational study also found that TDF was associated with an increased risk of renal adverse events,43 and a third observational study found that TDF was associated with kidney dysfunction, which was relatively mild and tended to be stable over several years.44
A cohort study found that ever use of TDF was associated with increased risk of fracture compared with nonuse (adjusted incidence rate ratio, 1.40 [95% CI, 1.05 to 1.70]) after more than 86,000 person-years followup. However, there was no difference in risk of fracture based on cumulative duration of use (adjusted incidence rate ratio per 5 years of exposure, 1.08 [95% CI, 0.94 to 1.25]).45
The USPSTF reviewed several studies that assessed the harms of ART during pregnancy.20 One fair-quality RCT and seven cohort studies found that antenatal ART was associated with increased risk of preterm birth (prior to 37 weeks of gestation) compared with no treatment or zidovudine monotherapy.46-53 No clear associations were found between ART and overall birth defects, low birth weight, small size for gestational age, stillbirth, or neonatal death.20 There were mixed findings on cardiovascular congenital anomalies.20 Two studies of HIV-exposed, uninfected infants and children found that in utero exposure to ART was not associated with lower scores on Wechsler intelligence and achievement tests in children ages 7 to 13 years,54 and may be associated with less neurodevelopmental impairment55 compared with no in utero exposure to ART.
Evidence on maternal harms associated with ART during pregnancy is limited. Three older studies suggest that ART (especially with a protease inhibitor) may be associated with an increased risk of gestational diabetes.56-58 One RCT found no difference in risk of anemia between combination ART (zidovudine, lamivudine, and ritonavir-boosted lopinavir) starting between 28 and 36 weeks of gestation versus zidovudine monotherapy starting from 34 to 36 weeks of gestation until onset of labor, followed by zidovudine and a single dose of nevirapine at the onset of labor.59 Another RCT found that treatment with zidovudine-based ART resulted in increased risk for maternal adverse events versus zidovudine monotherapy (21% vs. 17%; p=0.008), and increased risk of abnormalities in blood chemistries (5.8% vs. 1.3%; p<0.001), primarily elevated alanine aminotransferase levels.46
Estimate of Magnitude of Net Benefit
The USPSTF concludes with high certainty that early detection and treatment of HIV infection would result in substantial benefits. Screening for HIV infection in all adolescents and adults ages 15 to 65 years, persons at increased risk for infection, and pregnant women would allow for earlier and expanded detection of HIV infection, thus resulting in earlier medical and behavioral interventions and treatment.
The USPSTF found convincing evidence that early initiation of ART for HIV infection, regardless of CD4 cell count, improves clinical outcomes and reduces the risk of sexual transmission. The USPSTF found adequate evidence that the harms of early detection and treatment of HIV infection are small, and the clinical benefits of ART substantially outweigh the potential risks of treatment in persons living with HIV. The USPSTF also found convincing evidence that screening for HIV infection in pregnant women confers substantial clinical benefits, with adequate evidence that the potential harms are small.
On the basis of these findings, the USPSTF concludes with high certainty that early detection and treatment of HIV infection results in substantial net benefit.
How Does Evidence Fit With Biological Understanding?
Diagnosis and initiation of treatment for HIV infection at the earliest stage possible is associated with improved health outcomes. Screening with highly accurate tests allows for diagnosis in the relatively long preclinical phase of HIV infection. Early treatment with ART has been shown to effectively suppress viral load and decrease the risk of AIDS-related events, serious non–AIDS-related events, and death in persons living with HIV infection. Effective treatment also decreases risk of sexual transmission of HIV by suppressing viral load in infected persons. Diagnosis and effective treatment in pregnant women living with HIV decreases the risk of mother-to-child transmission by suppressing viral load and allowing for implementation of other prevention strategies (i.e., appropriate antiretroviral treatment of the newborn and counseling about avoidance of breastfeeding).
In 2013, the USPSTF recommended screening for HIV infection in adolescents and adults ages 15 to 65 years, screening in younger adolescents and older adults at increased risk, and screening in all pregnant women.60 The current updated recommendation continues to strongly recommend screening for HIV infection in adolescents and adults ages 15 to 65 years, younger adolescents and older adults at increased risk, and all pregnant women.
In 2006, the CDC recommended routine voluntary screening for HIV infection in all adolescents and adults ages 13 to 64 years, regardless of other recognized risk factors, unless the HIV prevalence was documented to be less than 0.1% within a patient community.9 The CDC recommends that all persons should be screened at least once in their lifetime and those with risk factors be screened more frequently (e.g., annually), and recently recommended that clinicians consider testing sexually active men who have sex with men more frequently (e.g., every 3 to 6 months) based on risk behaviors, community HIV prevalence, and other considerations.10
In 2009, the American College of Physicians recommended routine screening for HIV infection.61 The Infectious Diseases Society of America recommends routine screening for HIV infection in all sexually active adults and pregnant women.62 In 2017, ACOG reaffirmed a previous recommendation that all females ages 13 to 64 years be tested at least once in their lifetime and annually thereafter if they are assessed to have risk factors for HIV infection.63 The American Academy of Pediatrics recommends universal screening for HIV infection once between the ages of 15 and 18 years, and annual reassessment and testing of persons at increased risk.64 The American Academy of Family Physicians supports the 2013 USPSTF recommendations, except it recommends that routine screening begin at age 18 years and only adolescents at increased risk be tested at younger ages.65
The CDC,9 ACOG,11 American Academy of Pediatrics,66, 67 American College of Physicians,61 and American Academy of Family Physicians65 recommend routine screening for HIV infection in all pregnant women using an opt-out approach, and rapid screening for women who present in labor with unknown HIV status. The CDC9 and ACOG11 recommend repeat testing during the third trimester in women with risk factors and in women in high-incidence settings with a negative test earlier in pregnancy; the CDC9 notes that repeat testing in the third trimester may be considered for all women with a negative test early in pregnancy.
1. Centers for Disease Control and Prevention. HIV Surveillance Report, 2016. vol. 28. http://www.cdc.gov/hiv/library/reports/hiv-surveillance.html. Published November 2017. Accessed November 6, 2018.
2. Singh S, Song R, Johnson AS, McCray E, Hall HI. HIV incidence, prevalence and undiagnosed infections in U.S. men who have sex with men. Ann Intern Med. 2018;168(10):685-94.
3. Dailey AF, Hoots BE, Hall HI, et al. Vital signs: human immunodeficiency virus testing and diagnosis delays - United States. MMWR Morb Mortal Wkly Rep. 2017;66(47):1300-6.
4. Panel on Treatment of Pregnant Women with HIV Infection and Prevention of Perinatal Transmission. Recommendations for the Use of Antiretroviral Drugs in Pregnant Women With HIV Infection and Interventions to Reduce Perinatal HIV Transmission in the United States. http://aidsinfo.nih.gov/contentfiles/lvguidelines/PerinatalGL.pdf. Updated October 2018. Accessed November 6, 2018.
5. Nesheim SR, Wiener J, Fitz Harris LF, Lampe MA, Weidle PJ. Brief report: estimated incidence of perinatally acquired HIV infection in the United States, 1978-2013. J Acquir Immune Defic Syndr. 2017;76(5):461-4.
6. Little KM, Taylor AW, Borkowf CB, et al. Perinatal antiretroviral exposure and prevented mother-to-child HIV infections in the era of antiretroviral prophylaxis in the United States, 1994-2010. Pediatr Infect Dis J. 2017;36(1):66-71.
7. Centers for Disease Control and Prevention. Laboratory testing for the diagnosis of HIV infection: updated recommendations. https://stacks.cdc.gov/view/cdc/23447. Published June 2014. Accessed November 6, 2018.
8. Centers for Disease Control and Prevention. 2018 Quick Reference Guide: Recommended Laboratory HIV Testing Algorithm for Serum or Plasma Specimens. https://stacks.cdc.gov/view/cdc/50872. Updated January 2018. Accessed November 6, 2018.
9. Branson BM, Handsfield HH, Lampe MA, et al; Centers for Disease Control and Prevention (CDC). Revised recommendations for HIV testing of adults, adolescents, and pregnant women in health-care settings. MMWR Recomm Rep. 2006;55(RR-14):1-17.
10. DiNenno EA, Prejean J, Irwin K, et al. Recommendations for HIV screening of gay, bisexual, and other men who have sex with men - United States, 2017. MMWR Morb Mortal Wkly Rep. 2017;66(31):830-2.
11. American Congress of Obstetricians and Gynecologists. Committee opinion no. 635: prenatal and perinatal human immunodeficiency virus testing: expanded recommendations. Obstet Gynecol. 2011;125(6):1544-7.
12. U.S. Department of Health and Human Services. Clinical guidelines. AIDSinfo Web site. https://aidsinfo.nih.gov/guidelines/. Accessed November 8, 2018.
13. U.S. Preventive Services Task Force. Behavioral counseling interventions to prevent sexually transmitted infections: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;161(12):894-902.
14. The Community Guide. HIV/AIDS, STIs and pregnancy. https://www.thecommunityguide.org/topic/hivaids-stis-and-pregnancy. Accessed November 8, 2018.
15. HIV.gov. https://www.hiv.gov/. Accessed November 8, 2018.
16. Centers for Disease Control and Prevention. HIV/AIDS. https://www.cdc.gov/hiv/. Accessed November 8, 2018.
17. Centers for Disease Control and Prevention. Recommendations for HIV Prevention With Adults and Adolescents With HIV in the United States, 2014: Summary for Clinical Providers. https://stacks.cdc.gov/view/cdc/44065. Updated December 2016. Accessed November 8, 2018.
18. Centers for Disease Control and Prevention. HIV among pregnant women, infants, and children. http://www.cdc.gov/hiv/group/gender/pregnantwomen/index.html. Accessed November 6, 2018.
19. Chou R, Dana T, Grusing S, Bougatsos C. Screening for HIV Infection in Asymptomatic, Nonpregnant Adolescents and Adults: A Systematic Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 176. AHRQ Publication No. 18-05246-EF-1. Rockville, MD: Agency for Healthcare Research and Quality; 2018.
20. Selph S, Bougatsos C, Dana T, Grusing S, Chou R. Screening for HIV Infection in Pregnant Women: A Systematic Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 177. AHRQ Publication No. 18-05246-EF-2. Rockville, MD: Agency for Healthcare Research and Quality; 2018.
21. Centers for Disease Control and Prevention. Rapid HIV tests suitable for use in clinical settings (CLIA-moderate complexity). https://www.cdc.gov/hiv/pdf/testing/rapid-hiv-tests-clinical-moderate-complexity.pdf. Accessed November 6, 2018.
22. Cohen MS, Chen YQ, McCauley M, et al; HPTN 052 Study Team. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493-505.
23. Grinsztejn B, Hosseinipour MC, Ribaudo HJ, et al; HPTN 052-ACTG Study Team. Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial. Lancet Infect Dis. 2014;14(4):281-90.
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