Statin Use for the Primary Prevention of Cardiovascular Disease in Adults: Preventive Medication
August 23, 2022
Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.
|What does the USPSTF recommend?
|For adults aged 40 to 75 years who have 1 or more cardiovascular risk factors (ie, dyslipidemia, diabetes, hypertension, or smoking) and an estimated 10-year cardiovascular disease (CVD) risk of 10% or greater:
Initiate a statin.
For adults aged 40 to 75 years who have 1 or more cardiovascular risk factors (ie, dyslipidemia, diabetes, hypertension, or smoking) and an estimated 10-year CVD risk of 7.5% to less than 10%:
For adults 76 years or older:
|To whom does this recommendation apply?
|These recommendations apply to adults 40 years or older who do not already have CVD or signs or symptoms of CVD. They do not apply to adults with a low-density lipoprotein cholesterol level greater than 190 mg/dL (4.92 mmol/L) or known familial hypercholesterolemia. These populations are at very high risk for CVD and considerations on the use of statins in these populations can be found in other organization’s guidelines on management of hypercholesterolemia.
|This recommendation is consistent with the 2016 USPSTF recommendation.
|How to implement this recommendation?
|Consider the patient’s age.
|What additional information should clinicians know about this recommendation?
|Why is this recommendation and topic important?
|CVD is the leading cause of mortality in the US, accounting for more than 1 in 4 deaths. In 2019, there were an estimated 558,000 deaths caused by coronary heart disease and 109,000 deaths caused by ischemic stroke.
|What are additional tools and resources?
|Where to read the full recommendation statement?
|Visit the USPSTF website (https://www.uspreventiveservicestaskforce.org/uspstf/) or the JAMA website (https://jamanetwork.com/collections/44068/united-states-preventive-services-task-force) to read the full recommendation statement. This includes more details on the rationale of the recommendation, including benefits and harms; supporting evidence; and recommendations of others
The USPSTF recognizes that clinical decisions involve more considerations than evidence alone. Clinicians should understand the evidence but individualize decision-making to the specific patient or situation.