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Archived Evidence Summary: Aspirin

Other Supporting Document for Aspirin/NSAIDs for Prevention of Colorectal Cancer: Preventive Medication

Originally published on: October 27, 2014

This recommendation statement is currently archived and inactive. It should be used for historical purposes only. Click here for copyright and source information .

Disclaimer:Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.

Archived: Preface

The Use of Aspirin for Primary Prevention of Colorectal Cancer

Catherine Dubé, M.D., M.Sc.a; Alaa Rostom, M.D., M.Sc.a; Gabriela Lewin, M.D.b; Alexander Tsertsvadze, M.D., M.Sc.b; Catherine Code, M.D.c; Margaret Sampson, M.L.I.S.b; and David Moher, Ph.D.b


The authors of this article are responsible for its contents, including any clinical or treatment recommendations. No statement in this article should be construed as an official position of the U.S. Agency for Healthcare Research and Quality (AHRQ) or the U.S. Department of Health and Human Services.

Address correspondence to: Alaa Rostom M.D., M.Sc (Epi), FRPC, Division of Gastroenterology, University of Calgary Medical Clinic, 3330 Hospital Drive, NW G176, Calgary, Alberta, Canada T2N 4N1, E-mail: arostom@calgary.ca

This systematic review was first published in the Annals of Internal Medicine. Select for copyright and source information.

Archived: Abstract

Background: Aspirin for prevention of colorectal cancer is controversial.

Purpose: To examine the benefits and harms of aspirin chemoprevention.

Data Sources: MEDLINE®, 1966 to December 2006; EMBASE, 1980 to April 2005; CENTRAL, Cochrane Collaboration's registry of clinical trials; Cochrane Database of Systematic Reviews.

Study Selection: Two independent reviewers conducted multilevel screening to identify randomized, controlled trials (RCTs), case-control studies, and cohort studies of aspirin chemoprophylaxis. For harms, systematic reviews were sought.

Data Extraction: In duplicate, data were abstracted and checked and quality was assessed.

Data Synthesis: Regular use of aspirin reduced the incidence of colonic adenomas in RCTs (relative risk [RR], 0.82 [95% CI, 0.7 to 0.95]), case-control studies (RR, 0.87 [CI, 0.77 to 0.98]), and cohort studies (RR, 0.72 [CI, 0.61 to 0.85]). In cohort studies, regular use of aspirin was associated with RR reductions of 22% for incidence of colorectal cancer. Two RCTs of low-dose aspirin failed to show a protective effect. Data for colorectal cancer mortality were limited. Benefits from chemoprevention were more evident when aspirin was used at a high dose and for periods longer than 10 years. Aspirin use was associated with a dose-related increase in incidence of gastrointestinal complications.

Limitations: Important clinical and methodological heterogeneity in the definitions of regular use, dose, and duration of use of aspirin necessitated careful grouping for analysis.

Conclusions: Aspirin appears to be effective at reducing the incidence of colonic adenoma and colorectal cancer, especially if used in high doses for more than 10 years. However, the possible harms of such a practice require careful consideration. Further evaluation of the cost-effectiveness of chemoprevention compared with, and in combination with, a screening strategy is required.

Archived: Introduction

Cancer accounts for 23% of all deaths in the United States. It is the second leading cause of death after heart disease, and the leading cause of death in those younger than age 65 years. Colorectal cancer is the third most common type of cancer in both men and women and is the second and third leading cause of cancer-related deaths in men and women, respectively. In 2006, an estimated 148,610 new cases of colorectal cancer occurred and 51,170 patients died of this disease.1, 2

It is widely accepted that colorectal adenomatous polyps are the precursors of the vast majority of colorectal cancer cases, so the early detection and removal of these lesions are presumed to reduce the incidence and mortality of colorectal cancer. In addition, cases of cancer detected by screening may be in the early stage and therefore curable. Colorectal cancer has many characteristics of a disorder that would be amenable to screening, as recently reviewed by the U.S. Preventive Services Task Force (USPSTF).3 Several screening methods are available, but despite the evidence of effectiveness, widespread routine screening of eligible individuals by any method continues to be low in the United States.4-7

An alternative and possibly complementary strategy to screening is prevention. This can include a variety of lifestyle and dietary changes or, as is the focus of this review, aspirin chemoprevention. Several basic science, population-based, and clinical trials have suggested a protective effect of aspirin as well as nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, against colorectal adenomas and colorectal cancer. Since age is a major risk factor for colorectal cancer, with approximately 90% of cases occurring after age 50,1 aspirin may be a particularly attractive intervention; it has documented efficacy in both the primary and the secondary prevention of cardiovascular disease.3

However, aspirin is not risk free; it can increase the risk for hemorrhagic stroke and gastrointestinal bleeding.3 Potential harms must be considered in light of the possibly long period of aspirin exposure used for colorectal cancer prevention. Furthermore, reductions in colorectal cancer mortality with chemoprevention would have to be great enough to compete with the 21% mortality reduction achieved with simple biannual fecal occult blood testing, or with the 60% mortality reduction seen with flexible sigmoidoscopy for lesions within reach of the sigmoidoscope.

Furthermore, data suggest that sigmoidoscopy followed by colonoscopy when polyps are found could decrease colorectal cancer incidence by up to 80%.8 The USPSTF strongly recommends screening of men and women older than age 50 years (grade A recommendation).9 A preventive strategy using aspirin may still have a role as an adjunct treatment, but the benefits would have to balance increased risks; in addition, the cost-effectiveness of this strategy would need to be favorable. Finally, although adherence to colorectal cancer screening is poor, long-term adherence to therapy with a chemopreventive agent in otherwise healthy individuals will probably have a similar limitation.

We conducted this systematic review to examine the evidence on the effectiveness of aspirin for chemoprevention of colorectal adenomas, colorectal cancer, and colorectal cancer mortality, as well as the harms of aspirin use in this setting.

Archived: Methods

Data Sources

The search strategy was developed in MEDLINE® and modified for the other databases. The search was limited to English-language reports of human studies. Databases searched were MEDLINE®, 1966 to December (week 4) 2006; preMEDLINE®, through 5 April 2005; EMBASE, 1980 to week 14 of 2005 (publication years 2003 to 2005); and CENTRAL and the Cochrane Library, Issue 4, 2004. Beyond these dates, we surveyed several sources to ascertain additional potentially eligible studies. The PubMed Cancer subset was searched for non-MEDLINE® material. Terms were derived from the National Cancer Institute cancer topic searches for colorectal cancer and adenomatous polyps. A comprehensive retrieval strategy was derived from the indexing in both MEDLINE® and EMBASE, investigator-nominated terms, and previous reviews.10-12

A search strategy to find recent systematic reviews of aspirin that appeared to address harm was developed and run in MEDLINE® (2003 to December [week 4] 2006). The Cochrane Database of Systematic Reviews and Database of Abstracts of Reviews of Effects (DARE) (Cochrane Library, third quarter 2004) were searched for all systematic reviews related to aspirin, without date restrictions.

Study Selection

At each screening level, 2 members of the review team independently selected articles for inclusion, after an initial calibration exercise. After identifying potentially relevant articles in the initial screening level, team members assessed whether each article met the inclusion criteria. Conflicts were resolved by consensus. A third level of screening was included to discriminate the different study designs. Data were abstracted by one reviewer and checked by a second reviewer.

Randomized, controlled trials (RCTs); controlled clinical trials; and observational studies (cohort and case-control studies) of the efficacy or effectiveness of aspirin were considered for inclusion if they fulfilled the population and outcome criteria: Participants were at "average" risk for colorectal cancer (that is, they had no known risk factors for colorectal adenoma or colorectal cancer other than age); could have a personal or family history of colorectal adenoma; and could have a family history of sporadic colorectal cancer ("higher risk").

Studies of familial adenomatous polyposis or hereditary nonpolyposis colon cancer syndromes (Lynch I or II) were excluded because these syndromes account for a small percentage of colorectal cancer cases. Secondary prevention studies of patients with a history of colorectal cancer were also excluded. Included studies addressed the incidence of colorectal adenoma or colorectal cancer and reductions in colorectal cancer mortality or overall mortality.

We sought studies on gastrointestinal, cardiovascular, and renal harms associated with the aspirin use by identifying systematic reviews; we chose to identify reviews because of the large number of reviews on harms of aspirin already performed.

Data Extraction and Quality Assessment

Several members of the team extracted data independently by using a computerized Web-based system (SRS 4.0; Trialstat Corp., Ottawa, Ontario, Canada). The PICOS (participant, intervention/exposure, comparator, outcome and study design) approach was applied for data extraction. Predefined criteria from the USPSTF were used to assess the quality of included systematic reviews, trials, and observational studies, which were rated as "good," "fair," or "poor."13 This scale relies on 4 criteria for systematic reviews, 6 criteria for case-control studies, 7 criteria for cohort studies, and 7 criteria for RCTs. Studies with a "good" rating met all criteria, "fair" studies met at least 80% of criteria and had no fatal flaw, and "poor" studies met fewer than 80% of criteria or had a fatal flaw.

Data Synthesis and Analysis

An analytic framework was used to facilitate study grouping and subsequent data analysis in an effort to produce logical groupings and to minimize clinical heterogeneity. Studies were initially grouped by the disorder (that is, colorectal adenoma vs. colorectal cancer), study design, study sample, and medication exposure and were subsequently subcategorized according to measures of dose effect, duration of exposure, and secondary outcomes when reported. Definition of such categories as "regular use" can be found elsewhere.13

Harms data from the included systematic reviews were summarized and presented as a qualitative systematic review.

Results were combined numerically only if clinically and statistically appropriate. The effect measure chosen for synthesis was the relative risk (RR). In case-control studies, a direct estimate of the RR is not possible. The odds ratio (OR) may be estimated, however, and when event rates are low, as is the case here, the OR closely approximates the RR. In what follows, we simply refer to the RR.

Heterogeneity was assessed by using the I2 statistic. Studies were combined when the I2 value was 50% or less.14 Point estimates of the adjusted RRs and their 95% CIs were directly abstracted from the reports of primary studies. One source of heterogeneity may be study-to-study variation in the method of selecting confounders to adjust for and the final set of confounders chosen. Appendix Tables 1 and 2 summarize these characteristics for each study. Furthermore, the USPSTF report discusses the methodologic considerations in detail.13 Standard errors were computed by dividing the CI width by (2 X 1.96). For 1 study that did not report CIs,15 the standard error was calculated by using a CI imputed from 2 different estimates in the report. Quantitative synthesis was conducted by using inverse-variance weighting and a random-effects model.16

Role of the Funding Sources

The evidence synthesis upon which this article was based was funded by the Centers for Disease Control and Prevention (CDC) for the Agency for Healthcare Research and Quality (AHRQ) and the USPSTF. Its design, conduct, and reporting were based on specific directives from these agencies.

Archived: Results

Data Synthesis

Study Selection

The literature search for the comprehensive USPSTF report13 yielded 1790 potentially relevant bibliographic records addressing the use of aspirin, COX-2 inhibitors, and other nonaspirin NSAIDs (Figure). Aspirin chemoprophylaxis of colorectal cancer was the focus of 8 case-control studies,17-24 7 cohort studies,15, 25-30 and 2 RCTs,31, 32 and aspirin chemoprophylaxis of colorectal adenoma was the focus of 7 case-control studies,19, 33-38 4 cohort studies,26, 30, 39-41 and 3 RCTs31.42.43 (Appendix Table 3). A table of duplicate and companion articles is available in the AHRQ report.13 Twelve systematic reviews of the harms of aspirin3, 44-53, 57 were also identified.

Mortality

The Woman's Health Study (WHS)32 was a large good-quality RCT in which female health care providers who were older than age 45 years and had no history of cancer, cardiovascular disease, or other diseases were randomly assigned to either 100 mg of aspirin every other day or placebo and followed for 10 years. No statistically significant benefit of aspirin on colorectal cancer mortality was observed. A large, 6-year, fair-quality cohort study28 of adults treated with various aspirin doses found that regular aspirin use for longer than 15 years was associated with a significant reduction in colorectal cancer mortality in both men and women, whereas shorter durations of use yielded a protective effect in men only (Table 1).

Colorectal Cancer Incidence

Table 1 summarizes the effects of regular aspirin use on colorectal cancer incidence.

RCTs

One fair-quality RCT31 and 1 good-quality RCT32 from the United States assessed the effect of low-dose aspirin on colorectal cancer incidence. In the Physicians' Health Study,31 aspirin (325 mg every other day) for 5 years did not significantly reduce colorectal cancer incidence. Similarly, 100 mg of aspirin every other day for 10 years in the similarly designed Women's Health Study did not show a statistically significant reduction in colorectal cancer incidence.32

Cohort Studies

The effect of regular use of aspirin on the incidence of colorectal cancer in average-risk individuals was assessed in 7 cohort studies.15, 25-27, 29, 30, 54 One of these30 is a followup to a previous study.54 One poor-quality study was excluded from the pooled analysis because of its incomplete data presentation.15 Four of the remaining 5 studies were conducted in the United States,25-27, 54 while the other study was conducted in Denmark.29

The studies ranged in quality from fair to good and included a range of followup periods and methods of ascertaining aspirin use (Appendix Table 3). Quantitative synthesis of the data was possible for regular use of aspirin (that is, >2 to 3 times weekly for >1 year); this analysis showed a statistically significant 22% RR reduction in the incidence of colorectal cancer (Table 2). A large, good-quality, long-term followup study of aspirin use in average-risk U.S. women revealed a protective effect with more than 10 years of use (RR, 0.67 [CI, 0.54 to 0.85]) as well as for higher doses.30, 54

Case-Control Studies

Seven case-control studies assessed the effect of aspirin use on colorectal cancer incidence.17-21, 23, 24 Six studies were rated as fair quality, and 1 was rated as good quality.17 Significant heterogeneity, explained predominantly by differences in the methods of exposure and outcome ascertainment among these studies, precluded statistical pooling for the effect of regular use of aspirin on colorectal cancer frequency. These studies reported widely varying statistically significant reductions in the RR for colorectal cancer with regular aspirin use (RR, 0.3 to 0.7)19, 20, 24 or nonsignificant trends in favor of aspirin use (RR, 0.3 to 0.9).17, 18, 21, 23

The effect of duration of aspirin use on colorectal cancer frequency was assessed in 5 studies.17-19, 55, 56 Quantitative pooling of these results indicated that aspirin use lasting 1 to 3 years showed a nonsignificant trend in favor of aspirin (RR, 0.85 [CI, 0.72 to 1.0]), whereas longer duration of use was associated with a statistically significant protective effect (RR, 0.68 [CI, 0.54 to 0.87]).

Dose response was assessed in 1 small, fair-quality study17 and 1 larger, good-quality study.55 Statistically significant 40% RR reductions in colorectal cancer frequency were observed with aspirin dosages of 300 and 325 mg/d, but not for lower dosages.

Colorectal Adenoma Incidence

RCTs

The effect of aspirin on the incidence of colorectal adenomas was reported in 2 U.S. RCTs31.42 and 1 French RCT.43 Two of these studies were of good quality,42, 43 and 1 was of fair quality.31 Aspirin, 325 mg every other day for 5 years, did not significantly reduce the incidence of adenomas in average-risk men.31 However, in patients with a history of colorectal adenomas, the use of aspirin in dosages of 81 to 325 mg/d for 1 year resulted in a statistically significant reduction in the RR for adenoma (RR, 0.82 [CI, 0.7 to 0.95])42.43 (Table 1).

Cohort Studies

Two good-quality cohort studies in average-risk Americans revealed that regular aspirin use was associated with a statistically significant 28% RR reduction in the occurrence of colorectal adenomas.26, 30, 39 The reduction in adenoma risk was seen with the intake of at least six 325-mg aspirin tablets per week; the reduction was similar for small and large polyps and for polyps with advanced histologic features30, 39 (Table 1).

The effect of regular use of aspirin in patients with a history of colorectal adenoma was assessed in 2 small cohort studies.40, 41 In a good-quality study, aspirin used in dosages greater than 325 mg/d was associated with a statistically significant protective effect;41 in the other, a fair-quality study, consistent aspirin use (dose not reported) was also associated with a statistically significant risk reduction in adenomas40 (Table 1).

Case-Control Studies

In a combined analysis of 5 predominantly fair-quality studies lasting 3 to 10 years, the regular use of aspirin in average-risk individuals significantly reduced the incidence of colorectal adenomas19, 33-35, 37 (Table 1). A good quality database study revealed a nonsignificant trend in favor of higher aspirin doses and longer duration of use.35

A fair-quality U.S. study in a mixed population of patients with and without a history of colorectal adenoma did not show a statistically significant benefit of an intake of 15 aspirin tablets or more per month for at least 5 years.38 Another fair-quality study in patients with a history of adenomas showed a statistically significant reduction in the RR for adenomas in the subgroup of patients who used aspirin 4 times per week for more than 5 years compared with hospital controls.36 Comparisons with patients who used aspirin for less than 5 years or comparisons with population controls were nonsignificant (Table 1).

Harms Due to Aspirin Use

Twelve good-quality systematic reviews addressed the magnitude of harms due to aspirin use in an adult population.3, 44-53, 57 Eleven of these were systematic reviews of RCTs and provide high-level evidence, while 1 considered observational studies only.51 None addressed the nephrotoxicity of aspirin.

Six systematic reviews addressed general aspirin harms in the adult population.3, 44-47, 57 All-cause mortality was reported in all the reviews. However, mortality and withdrawals due to harms with aspirin use were not consistently reported.

Mortality

In the setting of primary prevention of cardiovascular disease, the all-cause mortality rate with aspirin compared with placebo was not statistically different3, 45, 57 For secondary prevention of cardiovascular disease, aspirin significantly reduced the RR for death from any cause by 15% to 18% compared with persons not receiving aspirin.46, 47

Cardiovascular Events

Eight systemic reviews addressed the magnitude of cardiovascular harms associated with aspirin use in an adult population.3, 44-49, 57 Cardiovascular events included acute myocardial infarction (MI), stroke (all, hemorrhagic, or ischemic), and associated death (Table 2).

Four reviews reported on the mortality due to cardiovascular events.3, 45, 46, 57 In a primary prevention setting, mortality due to cardiovascular events was not significantly different between aspirin and placebo.3, 45, 57 In the setting of secondary prevention, aspirin was associated with a statistically significant 16% reduction in the RR for mortality due to cardiovascular events.46 Seven reviews reported the risk for acute MI with aspirin use.3, 44-47, 49, 57 In the setting of primary prevention, a significantly lower risk for MI with aspirin compared with placebo was reported in 3 reviews.3.45.57 In a third review, although the data were not pooled, a significant absolute risk reduction in MI was reported in a trial that compared the use of aspirin with placebo in patients with hypertension (absolute risk reduction, 0.5%; number needed to treat for benefit, 200).49 In a secondary prevention setting, 2 reviews reported a significant 30% reduction in the RR for MI with aspirin use compared with placebo.46, 47

Seven systematic reviews reported the risk for acute stroke (hemorrhagic and ischemic) with aspirin use.3, 45-49, 57 In primary prevention trials, the risk for stroke did not differ between aspirin and placebo,3, 57 in healthy patients,45 in patients with vascular risk factors,45 or in patients with hypertension.49 One review also reported a nonsignificant OR of 1.4 for hemorrhagic stroke.3 In secondary prevention, the overall risk for stroke was not statistically different between aspirin and placebo.46, 47 However, the risk for hemorrhagic stroke was increased by 84% with aspirin.46 In secondary prevention trials, higher rates of hemorrhagic stroke were seen with higher dosages of aspirin (<100 mg/d, 0.3% [CI, 0.2% to 0.4%]; 100 to 325 mg/d, 0.3% [CI, 0.2% to 0.3%]; >325 mg/d, 1.1% [CI, 0.7% to 1.5%]),48 while the risk for ischemic stroke was decreased by 18%.46 The recent Women's Health Study32 suggests a possible differential effect of aspirin on women compared with men in the setting of cardiovascular primary prevention. While the Physicians' Health Study demonstrated a reduction in MI risk and no reduction in stroke, the Women's Health Study found no significant reduction in MI but a significant reduction in overall stroke and ischemic stroke.

Gastrointestinal Harms

Gastrointestinal harms of aspirin were considered in 7 systematic reviews.3.47, 48, 50-53 The included reviews summarized data from RCTs,3, 47, 48, 50, 52, 53, 58 cohort studies,3, 51, 53 and case-control studies,51, 52 and some considered low and high doses of aspirin.48, 59

Aspirin was consistently associated with a statistically significantly elevated risk for gastrointestinal bleeding. The magnitude of this increased RR ranged from 1.6 to 2.5 times that seen among persons who did not use aspirin in the systematic reviews of RCTs, 2.2 times in the systematic review of cohort studies, and 3.1 times in the systematic review of case-control studies. The use of aspirin was also associated with an increased risk for adverse gastrointestinal symptoms, such as nausea and dyspepsia (OR, 1.7 [CI, 1.5 to 1.8]).53

A dose effect has been suggested for aspirin-induced gastrointestinal toxicity. One systematic review pooled gastrointestinal bleeding incidence among large cardiovascular studies and found that 2.5% (CI, 2.2% to 2.6%) of patients taking more than 100 mg of aspirin per day had gastrointestinal bleeding compared with 1.1% (CI, 0.9% to 1.3%) of those taking fewer than 100 mg/d.48 Ulcer bleeding or perforation occurred in 0.34% and 0.86% of patients taking low-dose (325 mg every 2 days) and high-dose (2.5 to 5.2 g/d) aspirin, respectively (P < 0.05).52 Similarly, a greater risk for gastrointestinal bleeding was seen with high-dose aspirin (1600 mg) (OR, 2.8 [CI, 1.3 to 5.7]) than with lower doses (300 mg/d) (OR, 1.6 [CI, 0.7 to 4.0]).53 Another systematic review of RCTs demonstrated an increased risk for gastrointestinal bleeding with low-dose aspirin (50 to 162.5 mg) (RR, 1.59 [CI, 1.40 to 1.81]), but the rate of gastrointestinal bleeding with the somewhat higher dose (>162 mg) was not statistically different (RR, 1.68 [CI, 1.51 to 1.88]).50

It was estimated that 3 of 1000 middle-aged men would have gastrointestinal bleeding over a 5-year period of continuous aspirin use, and the rate would be as high as 2 per 1000 patients per year if older, higher-risk patients were considered.3 It has also been suggested that the gastrointestinal bleeding rate with aspirin (300 mg) is 60% higher than with placebo and represents an attributable rate of 2.5 events/1000 patient-years.53 The risk for hospitalization due to gastrointestinal bleeding is also increased (OR, 1.9 [CI, 1.1 to 3.1]), although death from gastrointestinal bleeding itself is rare.53 Of the reviews that reported on this latter outcome,47, 52, 53 only 1 death was recorded with aspirin use.53

Archived: Discussion

Colorectal cancer is a frequent cause of illness and death in the U.S. population. Chemoprevention with aspirin is one possible "simple" strategy to reduce the burden associated with this disease. Our results suggest that such a strategy may be effective, but careful consideration of some remaining inconsistencies in the literature, and the possible harms of chemoprevention, is required before such a strategy can be recommended.

The regular use of aspirin appears to reduce the incidence of colorectal adenoma with RR reductions on the order of 13% to 28% in average-risk individuals. On the basis of a limited number of studies, the RR reductions for individuals with a history of colonic adenoma are probably higher than for those at average risk. Furthermore, it appears that longer duration of aspirin use, as well as higher doses, are associated with greater RR reductions than shorter-term and lower-dose use.

The regular use of aspirin was associated with a pooled 22% RR reduction in colorectal cancer incidence among the included cohort studies. There was significant heterogeneity among the case-control studies, but the individual study results were consistent with a protective effect of aspirin.

Aspirin is a unique agent that may have preventive health benefits. While relatively low doses of aspirin appear to be sufficient for the cardiovascular benefits, it appears that prolonged use of higher doses of aspirin for more than 10 years is required to realize benefits for the chemoprevention of colorectal cancer. The widely cited Physicians' Health Study31 and the recently published Women's Health Study32 found no benefit of low-dose aspirin on colorectal cancer incidence. These RCTs shared many similarities, and the strength of their design adds weight to these negative findings. They were conducted in male physicians and female health care workers, respectively. Both used a relatively low dose of aspirin (325 mg every other day and 100 mg every other day, respectively), and both used self-reporting of outcomes in mailed questionnaires, as well as mailed medication packs. Both studies followed patients for a long period (14 and 10 years, respectively), but in the case of the Physicians' Health Study, the RCT portion made up the first 5 years, followed by an observational phase during which patients chose their intervention.

The Women's Health Study maintained the RCT design for the entire study period. The Physicians' Health Study could be criticized for its observational phase, which could have introduced several forms of bias, including contamination by intervention. In addition, study participants had a lower rate of colorectal cancer than matched members of the U.S. population, with a standardized mortality ratio of 0.82 (CI, 0.75 to 0.90). Participants in both studies were relatively young (mean age, 53.2 and 54.6 years, respectively), and they were not necessarily free of colorectal adenomas at study onset.

It is difficult to entirely reconcile the discrepancy between the negative RCT data and the generally positive observational data, other than saying that low-dose aspirin every other day does not reduce colorectal cancer incidence but that higher doses used for longer periods may be effective.

It is also fair to admit that the overall quality of the observational studies was only "fair" and that these studies exhibited considerable limitations in the ascertainment of aspirin exposure in particular. As a result, it was not always possible for us to pool the data. However, good-quality data from large-scale, long-term studies, such as the 82,911 women in the Nurses' Health Study,30 support our overall estimate that aspirin reduces the risk for colorectal cancer. However, this benefit occurs with dosages in the range of 14 or more standard aspirin tablets per week and use lasting for 10 or more years.

The data on colorectal cancer mortality are also inconsistent. One cohort study was positive, while the recently published Women's Health Study also showed no effect of aspirin on mortality. However, it is possible that dosage and duration effects are important in this setting as well, so that higher-dose aspirin for longer periods may still have a beneficial effect on colorectal cancer mortality.

The use of aspirin is associated with an increased incidence of important ulcer complications, with RRs of 1.5 to 3.0. Rates of gastrointestinal toxicity with aspirin appear to be between rates associated with diclofenac and sulindac.60 Aspirin also appears to have a dose effect: The absolute risks for gastrointestinal bleeding are 0.97% per year with a dosage less than 100 mg/d and 2.69% per year for a dosage greater than 200 mg/d.61 A dose effect was also demonstrated with the risk for hemorrhagic stroke. Therefore, the multiyear use of high-dose aspirin that appears to be required for colorectal cancer chemoprevention can be expected to be accompanied by important complications that may adversely affect the overall benefit of a chemoprevention strategy.

The cardiovascular outcomes associated with the use of aspirin depend on the underlying cardiovascular risk among the population under investigation. In low- to average-risk individuals (that is, those receiving primary cardiovascular prevention), aspirin significantly reduces the incidence of total cardiovascular events and myocardial infarction but has no effect on coronary heart disease mortality, fatal and nonfatal stroke events, or all-cause mortality. In low- to moderate-risk individuals, the use of aspirin would prevent 3 to 8 fatal or nonfatal coronary heart disease events, would not prevent an ischemic stroke event, and would cause 1 hemorrhagic stroke and 1 major gastrointestinal hemorrhage among 1000 treated patients.3

Data from the Women's Health Study suggest that the risk for stroke (overall as well as ischemic) is significantly reduced by aspirin use in women older than age 65 years.32 In high-risk patients with cardiovascular disease in a secondary prevention setting, the use of aspirin significantly reduces all-cause mortality and cardiovascular mortality, despite the increased incidence of major gastrointestinal hemorrhage. It is suggested that 67 patients would need to be treated to prevent 1 death, at the cost of 1 nonfatal gastrointestinal bleeding episode.47, 50 In the setting of colorectal cancer chemoprevention with aspirin, depending on the age at which the intervention is started, most patients may be at low to moderate cardiovascular risk and may have greater exposure to the harms of aspirin than to its benefits. This may be especially true if one considers that for colorectal cancer prevention, aspirin would need to be used in doses higher than currently recommend for cardiovascular prevention.

In average-risk populations and in the context of regular endoscopic screening for colorectal cancer, aspirin chemoprevention also must be weighted against the relatively large costs associated with its adverse effects, as well as the relative inefficacy of aspirin compared with colonoscopy screening.13

In conclusion, aspirin appears to reduce the incidence of colorectal adenomas and colorectal cancer. However, the data on colorectal cancer incidence are inconsistent: Observational studies tend to be positive, and 2 large RCTs showed no benefit for low-dose aspirin every other day.

The effect of aspirin on colorectal cancer mortality is also mixed, with 1 positive cohort study and negative findings of the Women's Health Study. The available data would suggest that for chemoprevention, aspirin would need to be used in doses greater than used for cardiovascular prevention and for a duration close to 10 years. Therefore, the potential benefit of aspirin chemoprevention would need to be carefully weighed against its harms. More information is still required to clarify the optimal dose, starting age, and duration of use of aspirin. In addition, its effect on colorectal cancer incidence and mortality should be clarified, particularly given the evidence that in patients at average cardiovascular risk, use of aspirin does not reduce all-cause mortality. Further evaluation of the cost-effectiveness of chemoprevention compared with, and in combination with, a screening strategy is required.

Archived: Notes, Copyright, and Source Information

Acknowledgments

The authors thank Mary White, Sc.D., Chief Epidemiology and Applied Research Branch, Centers for Disease Control and Prevention; Patrik Johansson, M.D., Medical Officer (AHRQ); Therese Miller, Dr.P.H., Task Order Officer (AHRQ); Janelle Guirguis-Blake, M.D., U.S. Preventive Services Task Force (USPSTF) Program Director; and Elizabeth A. Edgerton, M.D., M.P.H., Director of Clinical Prevention, for their contributions. Members of the USPSTF who served as leads for this project include Ned Calonge, M.D., M.P.H.; Michael LeFevre, M.D., M.S.P.H.; Carol Loveland-Cherry, Ph.D., R.N.; and Al Siu, M.D., M.S.P.H. The authors thank Nav Saloojee, M.D., for helping select relevant reports, Tiffany Richards for assisting with the evidence tables, Raymond Daniel for retrieving the full reports, and Chantelle Garritty for helping coordinate the process. The authors also thank Isabella Steffensen and Christine Murray, who dedicated many long hours in the editing of the report and the appendices.

Notes

Author Affiliation

a. Drs. Dubé and Rostom: Division of Gastroenterology, University of Calgary Medical Clinic, Calgary, Alberta, Canada.
b. Drs. Lewin, Tsertsvadze, Barrowman, Sampson, and Moher: Chalmers Research Group, CHEO Research Institute, Ottawa, Ontario Canada.
c. Dr. Code: Division of Internal Medicine, The Ottawa Hospital—Civic Site, Ottawa, Ontario Canada.

Copyright and Source Information

This document is in the public domain within the United States.

Requests for linking or to incorporate content in electronic resources should be sent via the USPSTF contact form.

Source: Dubé C, Rostom A, Lewin G, Tsertsvadze A, Barrowman N, Code C, Sampson M, Moher D. The use of aspirin for primary prevention of colorectal cancer: Systematic review for the U.S. Preventive Services Task Force. Ann Intern Med 2007;146:376-89.

Archived: Figure. Study Selection, Inclusion, and Exclusion at Each Screening Phase for the Efficacy End Points

Select Text Description below for details

Note: ASA = aspirin; CRA = colorectal adenoma; CRC = colorectal cancer; RCT = randomized, controlled trial.

Text Description.

Two diagrams depict the flow of the review process for this article.

The first diagram depicts records related to Efficacy End Points. The uppermost box in the diagram reads "Records identified with bibliographic databases and reviewer nomination (n = 1790)." Two arrows point down from this box to two other boxes beneath it; one reads "Records excluded from further review because of no apparent relevance (n = 1426)" and the other reads "Reports retrieved for relevance assessment (n = 364)"

From "Reports retrieved for relevance assessment (n = 364)," two arrows point down to two more boxes; one reads:

"Records excluded (n = 296):

  • No relevant population = 111.
  • No relevant intervention = 31.
  • No relevant outcome = 17.
  • Not an eligible study design = 135.
  • Unable to obtain = 2."

The second box reads:

"Studies included in the 68 reports that entered qualitative synthesis and were eligible for meta-analysis (n = 35):

  • RCTs (ASA: 3 CRA, 2 CRC): 5.
  • Cohort studies (ASA: 4 CRA, 7 CRC): 11.
  • Case-control studies (ASA: 7 CRA, 7 CRC): 14.
  • Cost-effectiveness analysis (ASA: 3): 3.

The second diagram depicts records related to Harms End Points. The uppermost box in the diagram reads "Records identified with bibliographic databases and reviewer nomination (n = 560)." Two arrows point down from this box to two other boxes beneath it; one box reads "Records excluded from further review because of lack of relevance (n = 442)" and the other reads "Reports retrieved for relevance assessment (n = 118)."

From "Reports retrieved for relevance assessment (n = 118)," two arrows point down to two more boxes; one reads:

"Records excluded (n = 90):

  • Inclusion criteria not met = 88.
  • Did not address relevant harm = 1.
  • Unable to obtain = 1."

The second box reads:

"Systematic reviews that entered qualitative synthesis (n = 28).
(12 of these considered harms of ASA."

Note: ASA = aspirin; CRA = colorectal adenoma; CRC = colorectal cancer; RCT = randomized, controlled trial.

Archived: Table 1. Effects of Regular Use of Aspirin on Colorectal Cancer Incidence and Mortality and on Adenoma Incidence

Design
(Studies)
Study (Reference)
(Participants; Quality Rating)
Population Dose and Duration of Regular Aspirin Use Relative Risk
(95% CI)
CRC mortality in average-risk persons
RCT
(n = 1)
Women's Health Study32
(n = 39,876; good)
Women Aspirin, 100 mg every other day for 10 y NR
Cohort
(n = 1)
Cancer Prevention Study II28
(n = 1,083,531; fair)
Men ≥15 y
<15 y
0.58 (0.36-0.93)
0.72 (0.52-0.99)
Women ≥15 y
<15 y
0.61 (0.38-0.97)
0.72 (0.51-1.02)
CRC incidence in average-risk persons
RCTs
(n = 2)
Physicians' Health Study31
(n = 22,071; fair)
Men Aspirin, 325 mg every other day for 5 y 0.97 (0.77-1.24)
Women's Health Study32
(n = 39,876; good)
Women Aspirin, 100 mg every other day for 10 y 0.97 (0.77-1.24)
  Summary: RR, 1.02 (0.84-1.25)
Cohort studies
(n = 6)
Physicians' Health Study25
(n = 22,071; poor)
Men Aspirin, 325 mg every other day for 12 y 1.03 (0.83-1.28)
Health Professionals Follow-up Study26
(n = 47,900; good)
Men 4 y 0.54 (0.34-0.83)
Leisure World Cohort15
(n = 13,979; poor)
Men 7-10 y 1.38 (CI not reported)
Nurses' Health Study30, 54
(n = 89,446; good)
Women 10 y 0.62 (0.44-0.86)
Leisure World Cohort15
(n = 13,979; poor)
Women 7-10 y 1.1 (CI not reported)
North Jutland Database29
(n = 29,470; fair)
Men and women 6 y 0.9 (0.7-1.1)
NHANES/NHEFS27
(n = 14,407; fair)
Men and women NR 0.85 (0.63-1.15)
  Summary: RR, 0.78 (0.63-0.97)
Case-control studies
(n = 7)
General Practice Research Database17
(n = 12,005; good)
Men and women >2 y 0.9 (0.8-1.1)
Wisconsin Cancer Reporting System23
(n = 845; fair)
Women >5 y 0.79 (0.46-1.36)
Juarranz, et al.21
(n = 502; fair)
Men and women NR 0.32 (0.09-1.10)
Multicenter Italian Case Control Study18
(n = 3248; fair)
Men and women 5 y 0.7 (0.5-1)
Melbourne Colorectal Cancer Study20
(n = 1442; fair)
Men and women NR 0.57 (0.41-0.79)
Roswell Park Tumor Registry19
(n = 2704; fair)
Men and women 6 y 0.33 (0.15-0.72)
Slattery, et al.24
(n = 3051; fair)
Men and women >5 y 0.7 (0.6-0.8)
Adenoma incidence in average-risk persons
RCTs
(n = 1)
Physicians' Health Study31
(n = 22,071; fair)
Men Aspirin, 325 mg every other day for 5 y 0.86 (0.68-1.1)
Cohort studies
(n = 2)
Health Professionals Follow-up Study26
(n = 47,900; good)
Men 4 y 0.65 (0.42-1.02)
Nurses' Health Study30, 54
(n = 89,446; good)
Women 10 y 0.61 (0.73-0.87)
  Summary: RR, 0.72 (0.61-0.85)
Case-control studies
(n = 5)
General Practice Research Database35
(n = 943,903; good)
Men and women 5 y 0.9 (0.6-1.3)
Morimoto, et al.34
(n = 1037; fair)
Men and women 3 y 0.7 (0.5-1.1)
Logan, et al.33
(n = 476; fair)
Men and women 7 y 0.55 (0.3-1.1)
Roswell Park Tumor Registry19
(n = 2704; fair)
Men and women 9 y 0.61 (0.26-1.4)
CPS-II37
(n = 177,939; poor)
Men 10 y 0.97 (0.89-1.06)
Women 10 y 0.85 (0.77-0.95)
  Summary: RR, 0.87 (0.77-0.98)
Adenoma incidence/frequency in patients with a history of colorectal adenoma
RCTs
(n = 2)
Aspirin/folate Prevention Study42
(n = 1121; good)
Men and women Aspirin, 81 mg/d or 325 mg/d for 1 y 0.96 (0.81-1.13)
Association pour la prevention par l'aspirine du cancer colorectal43
(n = 272; good)
Men and women Aspirin, 160 mg/d or 300 mg/d for 1 y 0.61 (0.37-0.99)
  Summary: 0.82 (0.70-0.95)
Cohort studies
(n = 2)
Polyp Prevention Study I40
(n = 864; fair)
Men and women "Consistent use" for 4 y 0.52 (0.31-0.89)
Polyp Prevention Study41
(n = 1905; good)
Men and women Aspirin, ≤325 mg/d for 4 y 0.82 (0.65-1.02)
Aspirin, >325 mg/d for 4 y 0.54 (0.3-0.96)
Case control studies
(n = 2)
Sandler, et al.38
(n = 492; fair)
Men and women Aspirin, >15 tablets/mo for 5 y 0.84 (0.5-1.43)
Breuer-Katschinski, et al.36
(n = 442; fair)
Men and women (hospital controls) Aspirin, >4 tablets/wk for <5 y 0.91 (0.32-2.64)
Aspirin, >4 tablets/wk for ≥5 y 0.09 (0.01-0.82)
Population controls Aspirin, >4 tablets/wk for <5 y 0.64 (0.26-1.56)
Aspirin, >4 tablets/wk for ≥5 y 0.18 (0.02-1.63)

CPS = Cancer Prevention Study; CRC = colorectal cancer; NHANES = National Health and Nutrition Examination Survey; NHEFS = NHANES I Epidemiologic Follow-up Study; NR = not reported; RCT = randomized, controlled trial; RR = relative risk.

Archived: Table 2. Cardiovascular Outcomes with Aspirin Use

Outcome Primary Cardiovascular Prevention Outcomes (95% CI) (Reference) Secondary Cardiovascular Prevention Outcomes (95% CI) (Reference)
All-cause mortality No difference
OR, 0.93 (0.84-1.02)4
RR, 0.94 (0.87-1.01)45, 57
Reduced
RR, 0.82 (0.70-0.99)47
RR, 0.85 (0.8-0.9)46
Cardiovascular mortality No difference
OR, 0.87 (0.70-1.09)4
RR, 0.93 (0.83-1.03)45
OR, 0.89 (0.72-1.10)57
 
Reduced
RR, 0.84 (0.79-0.90)46
Myocardial infarction Reduced
OR, 0.72 (0.60- 0.87)4
OR, 0.74 (0.68-0.82)45
OR, 0.76 (0.67-0.85)57
ARR, 0.5%; NNTB, 20049
 
Reduced
RR, 0.68 (0.62-0.74)46
RR, 0.70 (0.7-0.9)47
Stroke No difference
Overall: OR, 1.(0.85-1.23)4; OR, 0.95 (0.84-1.06)57
Healthy men: RR, 1.20 (0.96-1.49)45
Cardiovascular risk factors: RR, 1.02 (0.86-1.21)45
Hypertension: OR, 0.94 (0.76-1.17)49
 
Reduced (ischemic)
Overall: RR, 0.88 (0.76-1.02)46 and 0.8 (0.7-1.0)47
Ischemic: RR, 0.82 (0.73-0.92)46
Hemorrhagic stroke No difference
OR, 1.4 (0.9-2.0)4
 
Increased
RR, 1.84 (1.24-2.74)46

ARR = absolute risk reduction; NNTB = number needed to treat for benefit; OR = odds ratio; RR = relative risk.

References:
  1. Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C, et al. Cancer statistics, 2006. CA Cancer J Clin 2006;56:106-30. [PMID: 16514137]
  2. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, et al. Cancer statistics, 2005. CA Cancer J Clin 2005;55:10-30. [PMID: 15661684]
  3. Hayden M, Pignone M, Phillips C, Mulrow C. Aspirin for the primary prevention of cardiovascular events: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 2002;136:161-72. [PMID: 11790072]
  4. Centers for Disease Control and Prevention (CDC). Trends in screening for colorectal cancer-United States, 1997 and 1999. MMWR Morb Mortal Wkly Rep 2001;50:162-6. [PMID: 11393486]
  5. From the Centers for Disease Control and Prevention. Trends in screening for colorectal cancer-United States, 1997 and 1999. JAMA 2001;285:1570-1. [PMID: 11302136]
  6. Centers for Disease Control and Prevention (CDC). Colorectal cancer test use among persons aged . or . 50 years-United States, 2001. MMWR Morb Mortal Wkly Rep 2003;52:193-6. [PMID: 12653456]
  7. Seeff LC, Nadel MR, Klabunde CN, Thompson T, Shapiro JA, Vernon SW, et al. Patterns and predictors of colorectal cancer test use in the adult U.S. population. Cancer 2004;100:2093-103. [PMID: 15139050]
  8. Thiis-Evensen E, Hoff GS, Sauar J, Langmark F, Majak BM, Vatn MH. Population-based surveillance by colonoscopy: effect on the incidence of colorectal cancer. Telemark Polyp Study I. Scand J Gastroenterol 1999;34:414-20. [PMID: 10365903]
  9. U.S. Preventive Services Task Force. Screening for colorectal cancer: recommendation and rationale. Ann Intern Med 2002;137:129-31. [PMID: 12118971]
  10. Rostom A, Dubé C, Jolicoeur E, Boucher M, Joyce J. Gastroduodenal ulcers associated with the use of nonsteroidal anti-inflammatory drugs: a systematic review of preventative pharmacologic interventions. Technology Report Issue 38. 2004. Ottawa, Canada, CCOHTA.
  11. Rostom A, Dubé C, Wells G, Tugwell P, Welch V, Jolicoeur E, et al. Prevention of NSAID-induced gastroduodenal ulcers. Cochrane Database Syst Rev 2002:CD002296. [PMID: 12519573]
  12. Asano TK, McLeod RS. Non steroidal anti-inflammatory drugs (NSAID) and aspirin for preventing colorectal adenomas and carcinomas. Cochrane Database Syst Rev 2004:CD004079. [PMID: 15106236]
  13. Rostom A, Dubé C, Lewin G, Tsertsvadze A, Barrowman N, Code C, et al. Use of aspirin and NSAIDs to prevent colorectal cancer. Evidence synthesis prepared by the University of Ottawa Evidence-based Practice Center under contract no. 290-02-0021. Rockville, MD: Agency for Healthcare Research and Quality; 2006.
  14. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60. [PMID: 12958120]
  15. Paganini-Hill A. Aspirin and colorectal cancer: the Leisure World cohort revisited. Prev Med 1995;24:113-5. [PMID: 7597009]
  16. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88. [PMID: 3802833]
  17. García-Rodríguez LA, Huerta-Alvarez C. Reduced risk of colorectal cancer among long-term users of aspirin and nonaspirin nonsteroidal antiinflammatory drugs. Epidemiology 2001;12:88-93. [PMID: 11138826]
  18. La Vecchia C, Negri E, Franceschi S, Conti E, Montella M, Giacosa A, et al. Aspirin and colorectal cancer. Br J Cancer 1997;76:675-7. [PMID: 9303370]
  19. Suh O, Mettlin C, Petrelli NJ. Aspirin use, cancer, and polyps of the large bowel. Cancer 1993;72:1171-7. [PMID: 8339210]
  20. Kune GA, Kune S, Watson LF. Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res 1988;48:4399-404. [PMID: 3390835]
  21. Juarranz M, Calle-Purón ME, González-Navarro A, Regidor-Poyatos E, Soriano T, Martínez-Hernandez D, et al. Physical exercise, use of Plantago ovata and aspirin, and reduced risk of colon cancer. Eur J Cancer Prev 2002;11:465-72. [PMID: 12394244]
  22. Coogan PF, Rosenberg L, Louik C, Zauber AG, Stolley PD, Strom BL, et al. NSAIDs and risk of colorectal cancer according to presence or absence of family history of the disease. Cancer Causes Control 2000;11:249-55. [PMID: 10782659]
  23. Reeves MJ, Newcomb PA, Trentham-Dietz A, Storer BE, Remington PL. Nonsteroidal anti-inflammatory drug use and protection against colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 1996;5:955-60. [PMID: 8959316]
  24. Slattery ML, Samowitz W, Hoffman M, Ma KN, Levin TR, Neuhausen S. Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. Cancer Epidemiol Biomarkers Prev 2004;13:538-45. [PMID: 15066917]
  25. Stürmer T, Glynn RJ, Lee IM, Manson JE, Buring JE, Hennekens CH. Aspirin use and colorectal cancer: post-trial follow-up data from the Physicians' Health Study. Ann Intern Med 1998;128:713-20. [PMID: 9556464]
  26. Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Willett WC. Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med 1994;121:241-6. [PMID: 8037405]
  27. Schreinemachers DM, Everson RB. Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 1994;5:138-46. [PMID: 8172988]
  28. Thun MJ, Namboodiri MM, Heath CW Jr. Aspirin use and reduced risk of fatal colon cancer. N Engl J Med 1991;325:1593-6. [PMID: 1669840]
  29. Friis S, Sørensen HT, McLaughlin JK, Johnsen SP, Blot WJ, Olsen JH. A population-based cohort study of the risk of colorectal and other cancers among users of low-dose aspirin. Br J Cancer 2003;88:684-8. [PMID: 12618874]
  30. Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Curhan GC, Fuchs CS. Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA 2005;294:914-23. [PMID: 16118381]
  31.  Gann PH, Manson JE, Glynn RJ, Buring JE, Hennekens CH. Low-dose aspirin and incidence of colorectal tumors in a randomized trial. J Natl Cancer Inst 1993;85:1220-4. [PMID: 8331682]
  32. Cook NR, Lee IM, Gaziano JM, Gordon D, Ridker PM, Manson JE, et al. Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA 2005;294:47-55. [PMID: 15998890]
  33. Logan RF, Little J, Hawtin PG, Hardcastle JD. Effect of aspirin and nonsteroidal anti-inflammatory drugs on colorectal adenomas: case-control study of subjects participating in the Nottingham faecal occult blood screening programme. BMJ 1993;307:285-9. [PMID: 8374373]
  34. Morimoto LM, Newcomb PA, Ulrich CM, Bostick RM, Lais CJ, Potter JD. Risk factors for hyperplastic and adenomatous polyps: evidence for malignant potential? Cancer Epidemiol Biomarkers Prev 2002;11:1012-8. [PMID: 12376501]
  35. García Rodríguez LA, Huerta-Alvarez C. Reduced incidence of colorectal adenoma among long-term users of nonsteroidal antiinflammatory drugs: a pooled analysis of published studies and a new population-based study. Epidemiology 2000;11:376-81. [PMID: 10874542]
  36. Breuer-Katschinski B, Nemes K, Rump B, Leiendecker B, Marr A, Breuer N, et al. Long-term use of nonsteroidal antiinflammatory drugs and the risk of colorectal adenomas. The Colorectal Adenoma Study Group. Digestion 2000; 61:129-34. [PMID: 10705177]
  37. Kahn HS, Tatham LM, Thun MJ, Heath CW Jr. Risk factors for self-reported colon polyps. J Gen Intern Med 1998;13:303-10. [PMID: 9613885]
  38. Sandler RS, Galanko JC, Murray SC, Helm JF, Woosley JT. Aspirin and nonsteroidal anti-inflammatory agents and risk for colorectal adenomas. Gastroenterology 1998;114:441-7. [PMID: 9496933]
  39. Chan AT, Giovannucci EL, Schernhammer ES, Colditz GA, Hunter DJ, Willett WC, et al. A prospective study of aspirin use and the risk for colorectal adenoma. Ann Intern Med 2004;140:157-66. [PMID: 14757613]
  40. Greenberg ER, Baron JA, Freeman DH Jr, Mandel JS, Haile R. Reduced risk of large-bowel adenomas among aspirin users. The Polyp Prevention Study Group. J Natl Cancer Inst 1993;85:912-6. [PMID: 8492320]
  41. Polyp Prevention Study Group. Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States). Cancer Causes Control 2003;14:403-11. [PMID: 12946034]
  42. Baron JA, Cole BF, Sandler RS, Haile RW, Ahnen D, Bresalier R, et al. A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med 2003; 348:891-9. [PMID: 12621133]
  43. Benamouzig R, Deyra J, Martin A, Girard B, Jullian E, Piednoir B, et al. Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Gastroenterology 2003;125:328-36. [PMID: 12891533]
  44. Gibbs WJ, Fugate SE, Vesta KS. Optimal antithrombotic management of anticoagulated patients with a history of myocardial infarction. Cardiol Rev 2004;12:327-33. [PMID: 15476572]
  45. Hart RG, Halperin JL, McBride R, Benavente O, Man-Son-Hing M, Kronmal RA. Aspirin for the primary prevention of stroke and other major vascular events: meta-analysis and hypotheses. Arch Neurol 2000;57:326-32. [PMID: 10714657]
  46. He J, Whelton PK, Vu B, Klag MJ. Aspirin and risk of hemorrhagic stroke: a meta-analysis of randomized controlled trials. JAMA 1998;280:1930-5. [PMID: 9851479]
  47. Weisman SM, Graham DY. Evaluation of the benefits and risks of low-dose aspirin in the secondary prevention of cardiovascular and cerebrovascular events. Arch Intern Med 2002;162:2197-202. [PMID: 12390062]
  48. Serebruany VL, Malinin AI, Eisert RM, Sane DC. Risk of bleeding complications with antiplatelet agents: meta-analysis of 338, 191 patients enrolled in 50 randomized controlled trials. Am J Hematol 2004;75:40-7. [PMID: 14695631]
  49. Lip GY, Felmeden DC. Antiplatelet agents and anticoagulants for hypertension. Cochrane Database Syst Rev 2004:CD003186. [PMID: 15266473]
  50. Derry S, Loke YK. Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis. BMJ 2000;321:1183-7. [PMID: 11073508]
  51. García Rodríguez LA, Hernández-Díaz S, de Abajo FJ. Association between aspirin and upper gastrointestinal complications: systematic review of epidemiologic studies. Br J Clin Pharmacol 2001;52:563-71. [PMID: 11736865]
  52. Tramèr MR, Moore RA, Reynolds DJ, McQuay HJ. Quantitative estimation of rare adverse events which follow a biological progression: a new model applied to chronic NSAID use. Pain 2000;85:169-82. [PMID: 10692616]
  53. Roderick PJ, Wilkes HC, Meade TW. The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials. Br J Clin Pharmacol 1993;35: 219-26. [PMID: 8471398]
  54. Giovannucci E, Egan KM, Hunter DJ, Stampfer MJ, Colditz GA, Willett WC, et al. Aspirin and the risk of colorectal cancer in women. N Engl J Med 1995;333:609-14. [PMID: 7637720]
  55. Rosenberg L, Louik C, Shapiro S. Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma. Cancer 1998;82:2326-33. [PMID: 9635524]
  56. Friedman GD, Coates AO, Potter JD, Slattery ML. Drugs and colon cancer. Pharmacoepidemiol Drug Saf 1998;7:99-106. [PMID: 15073733]
  57. Bartolucci AA, Howard G. Meta-analysis of data from the six primary prevention trials of cardiovascular events using aspirin. Am J Cardiol 2006;98:746-50. [PMID: 16950176]
  58. Main C, Palmer S, Griffin S, Jones L, Orton V, Sculpher M, et al. Clopidogrel used in combination with aspirin compared with aspirin alone in the treatment of non-ST-segment-elevation acute coronary syndromes: a systematic review and economic evaluation. Health Technol Assess 2004;8:iii-iv, xv-xvi, 1-141. [PMID: 15461878]
  59. Wang WH, Huang JQ, Zheng GF, Lam SK, Karlberg J, Wong BC. Nonsteroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis. J Natl Cancer Inst 2003;95:1784-91. [PMID: 14652240]
  60. Henry D, Lim LL, Garcia Rodriguez LA, Perez Gutthann S, Carson JL, Griffin M, et al. Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis. BMJ 1996;312:1563-6. [PMID: 8664664]
  61. Serebruany VL, Steinhubl SR, Berger PB, Malinin AI, Baggish JS, Bhatt DL, et al. Analysis of risk of bleeding complications after different doses of aspirin in 192, 036 patients enrolled in 31 randomized controlled trials. Am J Cardiol 2005;95:1218-22. [PMID: 15877994]

Archived: Appendix Table 1. Confounders Controlled for in the Studies' Adjusted Relative Risk Estimates for the Incidence of Colorectal Cancer (Cohort and Case-Control Studies)(

Study, Year
(Reference)
Source of Abstracted Data Methods for Selecting Confounders Confounders Individual Study Estimate RR
(95% CI)
Index of Heterogeneity and Pooled Estimate; RR
(95% CI)
Cohort studies: duration of aspirin use (7-9 y) and risk for CRC
Friis, et al., 200329 Table 3
(p. 687)
A priorib Age, sex (women and men) 0.90 (0.70-1.10)  
Giovannucci, et al., 199554 Table 2
(p. 612)
A prioric Age, sex (women) 0.84 (0.55-1.28)  
Stürmer, et al., 199825 Table 4 Stepwise model-based selection Age, sex (men), BMI, smoking, alcohol consumption 1.07 (0.67-1.70)  
  I2 = 0
RR = 0.91 (0.76-1.10)
Cohort studies: regular aspirin use (&e;2-3 d per week for &e;1 y) and risk for CRC
Stürmer, et al., 199825 Table 4 Stepwise model-based selection Age, sex (men), BMI, smoking, alcohol consumption 1.07 (0.67-1.70)  
Giovannucci, et al., 199426 Table 2
(p. 243)
A priorid Age; sex (men); family history of CRC; pack-years of smoking; BMI; physical activity levels; alcohol consumption; dietary intake of fat, meat, calcium, and vitamin D 0.54 (0.34-0.83)  
Giovannucci, et al., 199554 Table 1
(p. 611)
A priorid Age; sex (women); family history of CRC; pack-years of smoking; BMI; physical activity levels; alcohol consumption; dietary intake of fat, meat, calcium, and vitamin D 0.62 (0.44-0.86)  
Friis, et al., 200329 Table 3
(p. 687)
A priorib Age, sex (women and men) 0.90 (0.70-1.10)  
Schreinemachers and Everson, 199427   A priorid Age, sex (women and men) 0.85 (0.63-1.15)  
  I2 = 49
RR = 0.78 (0.63-0.97)
Case-control studies: duration of aspirin use (1-3 y) and risk for CRC
La Vecchia, et al., 199718 Table 2
(p. 676)
Stepwise model-based selection Age, sex (women and men), center, education, BMI, alcohol consumption, physical activity, total energy, and meat intake 0.90 (0.50-1.70)  
Friedman, et al., 199856 Table 2
(p. 101)
A priori and stepwise model-based selection Age; sex (women and men); use of NSAIDs; alcohol consumption; family history of CRC; BMI; physical activity; smoking; total energy; fiber, calcium, and meat intake 0.80 (0.60-1.00)  
Rosenberg, et al., 199855 Table 4
(p. 2331)
Stepwise model-based selection Age; sex (women and men) 1.00 (0.60-1.70)  
García-Rodríguez and Huerta-Alvarez, 200117 Table 6
(p. 92)
A priori and stepwise model-based selectione Age; sex (women and men) 0.90 (0.70-1.20)  
Slatterly et al., 200424 Table 2
(p. 216)
A priori and stepwise model-based selectionf Age, sex (men and women), alcohol consumption, family history of CRC, BMI, smoking, education, dietary fiber intake 0.54 (0.24-1.23)  
  I2 = 0
RR = 0.85 (0.72-1.00)
Case-control studies: duration of aspirin use (4-6 y) and risk for CRC
La Vecchia, et al., 199718 Table 2
(p. 676)
Stepwise model-based selection Age, sex (women and men), center, education, BMI, alcohol consumption, physical activity, total energy, and meat intake 0.60 (0.40-1.00)  
Friedman, et al., 199856 Table 2
(p. 101)
A priori and stepwise model-based selection Age; sex (women and men); use of NSAIDs; alcohol consumption; family history of CRC; BMI; physical activity; smoking; total energy; fiber, calcium, and meat intake 0.80 (0.60-0.90)  
Rosenberg, et al., 199855 Table 4
(p. 2331)
Stepwise model-based selection Age; sex (women and men) 0.50 (0.30-0.70)  
García-Rodríguez and Huerta-Alvarez, 200117 Table 6
(p. 92)
A priori and stepwise model-based selectione Age; sex (women and men) 0.90 (0.70-1.20)  
  I2 = 39
RR = 0.74 (0.60-0.90)
Case-control studies: recency (>1 y) of aspirin use and risk for CRC
Friedman, et al., 199856 Table 2
(p. 101)
A priori and stepwise model-based selection Age; sex (women and men); use of NSAIDs; alcohol consumption; family history of CRC; BMI; physical activity; smoking; total energy; fiber, calcium, and meat intake 1.00 (0.80-1.20)  
La Vecchia, et al., 199718 Table 2
(p. 676)
Stepwise model-based selection Age, sex (women and men), center, education, BMI, alcohol consumption, physical activity, total energy, and meat intake 0.90 (0.50-1.60)  
García-Rodríguez and Huerta-Alvarez, 200117 Table 6
(p. 92)
A priori and stepwise model-based selectione Age; sex (women and men) 1.00 (0.70-1.30)  
  I2 = 0
RR = 0.99 (0.84-1.17)

*. BMI = body mass index; CRC = colorectal cancer; NSAIDs = nonsteroidal anti-inflammatory drugs; RR = relative risk.
b. The authors calculated standardized incidence ratio, which incorporates age- and sex-specific cancer rates in population.
c. Cox proportional-hazards modeling (adjusted for age).
d. Cox proportional-hazards modeling (adjusted for potential confounders).
e. Poisson regression modelling.
f. Unconditional logistic regression model.

Archived: Appendix Table 2. Confounders Controlled for in the Studies' Adjusted Relative Risk Estimates for the Incidence of Colorectal Adenoma (Cohort and Case-Control Studies)*

Study, Year
(Reference)
Source of Abstracted Data Methods for Selecting Confounders Confounders Individual Study Estimate RR
(95% CI)
Index of Heterogeneity and Pooled Estimate; RR
(95% CI)
Cohort studies: regular aspirin use (>2-3 d per week for >1 y) and risk for adenomas
Giovannucci, et al., 199426 Table 4
(p. 244)
A priori Age; sex (men); family history of CRC; pack-years of smoking; BMI; physical activity levels; dietary intake of fat, meat, calcium, alcohol, and vitamin D 0.65 (0.42-1.02)  
Chan, et al., 200439 Table 3
(p. 161)
A priori and stepwise model-based selection Age; sex (women); pack-years of smoking; BMI; physical activity levels; history of CRC in sibling or parent; alcohol intake; postmenopausal HRT; meat, calcium, and vitamin intake 0.73 (0.61-0.87)  
  I2 = 0
RR = 0.72 (0.61-0.85)
Case-control studies: regular aspirin use and risk for adenomas
Morimoto, et al., 200234 Table 3
(p. 1016)
Backwards stepwise model-based selection Age, sex, BMI, HRT, pack-years of smoking, alcohol consumption 0.70 (0.50-1.10)  
Kahn, et al., 199837 Table 3
(p. 307)
Stepwise model-based selection Age; education; race; gallbladder status; BMI; exercise; smoking; alcohol and coffee consumption; multivitamin use; family history of CRC; dietary intake of eggs, vegetables, and meat 0.97 (0.89-1.06)
Sample of men
 
Kahn, et al., 199837 Table 3
(p. 307)
Stepwise model-based selection Same as in men, plus parity, HRT, and menopausal status 0.85 (0.77-0.95)
Sample of women
 
Suh, et al., 199319 Table 2
(p. 1174)
A priori and stepwise model-based selection Age, sex, residence, and level of education 0.61 (0.26-1.40)  
García-Rodríguez and Huerta-Alvarez, 200035 Table 5
(p. 380)
Stepwise model-based selection Age, sex, ischemic heart disease, constipation 0.90 (0.60-1.30)  
Logan, et al., 199333 Table 2
(p. 286)
A priori and stepwise model-based selection Age- and sex-matched case-patients and controls 0.55 (0.30-1.10)  

* BMI = body mass index; CRC = colorectal cancer; HRT = hormone replacement therapy; RR = relative risk.
† Multiple logistic regression model.

Archived: Appendix Table 3. Included Studies: Aspirin Chemoprevention of Colonic Adenomas and Colorectal Cancer, by Study Design*

Study, Year, Location
(Reference)
Participants Enrolled/ Completed Study, n/n Dur- ation Case-Patients Controls Exposure
(Ascertainment)
Quality Rating
Colorectal Cancer—Case-Control Studies (n = 7)
García Rodriguez, et al., 2001, Spain17 12,005/ 12,002 3 y Persons age 40-79 y with biopsy-proven CRC from the General Practice Research Database (n = 2002) Randomly selected persons age 40-79 y free of CRC at the index date of case (n = 10,000), frequency-matched by sex and age to case-patients Nonaspirin NSAIDs and aspirin (prescription drug database) Good
La Vecchia, et al., 1997, Italy18 3248/3248 4.5 y Patients with histologically confirmed CRC (n = 860 colon; n = 497 rectum) Patients in same residing area/hospital as case-patients, identified for acute conditions unrelated to known or likely risk factors for CRC (n = 1891 Aspirin (questionnaire) Fair
Suh, et al., 1993, U.S19 2704/NR 9 y Case-patients 1: first primary colon cancer (n = 490)

Case-patients 2: first primary rectal cancer (n = 340)
Controls 1: Healthy persons at preventive health visit (n = 1138)

Controls 2: healthy persons without cancer (n = 524)
Aspirin (questionnaire) Fair
Kune, et al., 1988, Australia20 1442/1367 1 y Persons with newly diagnosed CRC between April 1980 and April 1981 (n = 715) Randomly selected patients matched for age, sex, and geographic area Aspirin, NSAID (questionnaire) Fair
Juarranz, et al., 2002, Spain21 502/424 NR Patients with biopsy-proven colon cancer between January 1995 and December 1996, residing in Madrid (n = 196) Persons free of neoplasm or severe digestive disease (Crohn disease or ulcerative colitis) at enrollment, randomly chosen from electoral lists from same area as case-patients and matched to case-patients for age and sex Aspirin and NSAIDs (questionnaire) Fair
Reeves, et al., 1996, U.S.23] 845/400 1 y Women age 40-74 y, local residents with new diagnosis of invasive cancer of the colon or rectum, with listed telephone number (n = 184) Persons with listed telephone number and either a current Wisconsin driver's license (age < 65 y) or a Medicare card (age > 65 y) (n = 293) Aspirin, NSAID (questionnaire) Fair
Slattery, et al., 1996, U.S.[[24 3051/2157 5 y, 2 mo English-speaking persons mentally competent to complete the interview, age 30-79 y; first primary tumor in the rectosigmoid junction or rectum diagnosed between May 1997 and May 2001 (n = 952) Patients matched by sex and 5-y age group; those > age 65 y randomly selected from Health Care Financing Administration lists; those < age 65 y selected from driver's license lists (n = 1205) Aspirin, NSAID (questionnaire) Fair

 

Study, Year, Location
(Reference)
Participants Enrolled/Completed Study, n/n Study Duration Population Cohort Name Exposure Quality Rating
Colorectal Cancer—Cohort Studies (n = 7)
Chan, et al., 2005, U.S.30 89,446/ 82,911 20 y Inclusion criteria: female registered nurses age 30-55 y (in 1976).

Exclusion criteria: baseline cancer, did not fill out questionnaire.
Nurses' Health Study Aspirin.
Nonaspirin NSAIDs.

Assessed tablets/week (1-3, 4-6, 7-14, >14); number of days/month of use; frequency per week; regular use
Good
Giovannucci, et al., 1994, U.S.26 47,900/ 45,505 7 y Inclusion criteria: Male health professionals; respondents to mailed questionnaire in 1986; age 40-75 y.

Exclusion criteria: NR
Health Professionals Follow-up Study Aspirin: in all 3 questionnaires (n = 11,260 person-years) in CRC study.

Nonexposed: n = 30,020 person-years in CRC study.
Good
Schreinemachers, et al., 1994, U.S.27 14,407/ 12,668 16 y Inclusion criteria: Patients with medical examination and age 25-74 y at time of NHANES I.

Exclusion criteria: Case-patients: diagnosis occurring ≥ 2 y of NHANES I; controls: incomplete surveys or data on aspirin use.
NHANES/NHEFS Aspirin: within 30 d of baseline interview (n = 7438).

Nonexposed: within 30 d of baseline interview (n = 5250).
Fair
Thun, et al., 1991, U.S.28 1,083,531/ 662,424 6 y Inclusion criteria: White adults (friends/family of volunteers for Cancer Prevention Study II in 1982) who provided information in 1982 on the frequency and duration of aspirin use.

Exclusion criteria: Nonwhite (due to small number of deaths in this group); aspirin use <1 y.
Cancer Prevention Study II Aspirin: <1 time/mo (n = 486,620 person-years for men and n = 671,927 person-years for women); 1-15 times/mo (389,083 person-years for men and 505,854 person-years for women); ≥ 16 times/mo (n = 201,638 person-years for men and n = 265,424 person-years for women).

Nonexposed: n = 646,346 person-years for men and n = 705,064 person-years for women.
Fair
Friis, et al., 2003, Denmark29 29,470/ 29,470 9 y Inclusion criteria: Patients with prescribed low-dose aspirin (maximum dose, 150 mg), Danish Cancer registry, controlled for age, sex, and county.

Exclusion criteria: Residency outside county of North Jutland; invalid civil registry number; death before/at date of prescription; parent (of patient) registered as customer.
North Jutland cohort database Low-dose aspirin (followup: 6 y): n = 29,470 Fair
Paganini-Hill, 1995, U.S.15 13,979/ 12,180 11 y Inclusion criteria: Community residents with returned questionnaire on medical history; use of drugs, laxatives, and supplements; smoking; alcohol consumption; exercise habits; health care utilization; and, for women, menstrual history (i.e., use of estrogen).

Exclusion criteria: NR
Leisure World Cohort Aspirin: Less than daily or daily Poor
Stürmer, et al, 1998, U.S.25 22,071/ 22,071 12 y (RCT, first 5 y; cohort study, next 7 y) Inclusion criteria: U.S. male physicians, age 40-84 y in 1982.

Exclusion criteria: Regular use of aspirin or other NSAIDs; history of myocardial infarction, stroke, cancer, liver or renal disease, gout, peptic ulcer, or contraindications to aspirin.
Physicians' Health Study Randomly assigned to aspirin/regular aspirin use thereafter (n = 41,869 person-years); randomly assigned to placebo/irregular aspirin use thereafter (n = 18,342 person-years) Poor

 

Study, Year, Location
(Reference)
Participants Enrolled/Completed Study, n/n Study Duration Population Control Group Exposure(s) Quality Rating
Colorectal Cancer—RCTs (n = 2)
Gann, et al., 1993, U.S.31 22,071/ NR 6 y Inclusion criteria: U.S. male physicians, age 40-84 y.

Exclusion criteria: History of CVD, cancer, liver or renal disease, gout, peptic ulcer, contraindications to aspirin, or current use of NSAIDs or vitamin A.
Placebo Aspirin Fair
Cook, et al., 2005, U.S.32 39,876 (39,876/ 39,876) 10 y Inclusion criteria: U.S. female health care workers age >45 y, no history of cancer, CVD, or other major disease.

Exclusion criteria: Sensitivity to aspirin; aspirin use >1 time/wk; use of oral anticoagulants, vitamin A or E supplements.
Placebo Aspirin, 100 mg every other day Good

 

Study, Year, Location
(Reference)
Participants Enrolled/Completed Study, n/n Study Dur- ation Population Cohort Name Exposure Quality Rating
Colonic Adenomas—Cohort Studies (n = 4)
Giovannucci, et al., 1994, U.S.26 47,900/ 45,505 7 y Inclusion criteria: Male health professionals; respondents to mailed questionnaire in 1986; age 40-75 y.

Exclusion criteria: NR
Health Professionals Follow-up Study Aspirin: in all 3 questionnaires (n = 11,260 person-years) in CRC study.

Aspirin: n = 1242 person-years in 1986 survey only.

Nonexposed: n = 30,020 person-years in CRC study.

Nonexposed: n = 2472 person-years in adenoma study.
Good
Chan, et al., 2004, U.S.30, 39 27,077/ 27,077 21 y Inclusion criteria: Women (registered U.S. nurses), age 30-55 y, who completed baseline dietary questionnaire and underwent colonoscopy or sigmoidoscopy during study period.

Exclusion criteria: Incomplete questionnaires; no data/implausible dietary/aspirin data; history of cancer (except nonmelanoma skin cancer), CRA, IBD, or FAP.
Nurses' Health Study Aspirin: 0.5-1.5 tablets/wk: n = 6340; 2-5 tablets/wk: n = 4172; 6-14 tablets/wk: n = 4352; >14 tablets/wk: n = 1634.

Nonexposed: n = 10,579
Good
Polyp Prevention Study, 2003, U.S.41 NR/1905 4 y Inclusion criteria: Enrollees of the Polyp Prevention Trial, 1991, ≥ age 35 y with ≥1 histologically confirmed colorectal adenoma identified by complete colonoscopy within 6 mo before randomization.

Exclusion criteria: History of colorectal cancer, surgical resection of adenomas, IBD, or FAP.
Polyp Prevention Study Aspirin: any use (n = 431); up to 325 mg/d (n = 369); > 325 mg/d (n = 62); unexposed (n = 1474); NSAID: any use (n = 629); unexposed (n = 1276); use reported at all 5 visits (n = 253); no use reported at all 5 visits (n = 1462) Good
Greenberg, et al., 1993, U.S.40 864/793 ~4 y Inclusion criteria: Patients with ≥ 1 histologically confirmed adenoma removed within 3 mo before study entry, free of further polyps, age < 80 y, otherwise healthy.

Exclusion criteria: Invasive large-bowel cancer; IBD; malabsorption; or any contraindication to β-carotene, vitamin C, vitamin E (history of kidney stones or thrombophlebitis).
Polyp Prevention Study I Aspirin: consistent use (n = 102).
Aspirin: intermittent use (n = 98).
Nonexposed: n = 593
Fair

 

Study, Year, Location
(Reference)
Participants Enrolled/Completed Study, n/n Study Dur- ation Population Study Name Exposure Quality Rating
Colonic Adenomas—RCTs (n = 3)
Gann, et al., 1993, U.S.31 22,071/ NR 6 y Inclusion criteria: U.S. male physicians, age 40-84 y.

Exclusion criteria: History of CVD, cancer, liver or renal disease, gout, peptic ulcer, contraindications to aspirin, or current use of NSAIDs or vitamin A.
Physician's Health Study Aspirin vs. placebo Fair
Baron, et al., 2003, U.S.42 1121/1084 7 y Inclusion criteria: Healthy patients age 21-80 y; ≥ 1 histologically confirmed CRA removed within 3 mo, or within 16 mo with history of ≥ 2 confirmed CRAs, or a histologically confirmed adenoma ≥ 1 cm in diameter removed within 16 mo; complete colonoscopy within 3 mo with no colorectal polyps remaining.

Exclusion criteria: History of familial CRC syndrome; invasive large-bowel cancer; malabsorption syndromes; contraindications to aspirin, NSAIDs, or folate.
Aspirin/Folate Prevention Study Aspirin, 81 mg/d, vs. aspirin, 325 mg, vs. placebo Good
Benamouzig, et al., 2003, France43 272/238 >8 y Inclusion criteria: Patients age 18-75 y with ≥3 CRAs of any size or 1 CRA ≥6 mm in diameter; no regular use of aspirin or other NSAIDs (7 consecutive d >3 wk/y or >21 d/y); removed polyps <3 mo after consultation; clean colon/rectum at entry; eligible women: menopausal or using efficient contraception.

Exclusion criteria: History of CRC, FAP, bowel resection excluding appendectomy, IBD, or debilitating or life-threatening diagnosis.
Association pour la prèvention par l'aspirin du colorectal cancer Lysine acetylsalicylate, 160 mg/d (n = 73), vs. lysine acetylsalicylate, 300 mg/d (n = 67), vs. placebo Good

 

Study, Year, Location
(Reference)
Participants Enrolled/ Completed Study, n/n Dur- ation Case-Patients Controls Exposure
(Ascertainment)
Quality Rating
Colonic Adenomas—Case-Control Studies (n = 7)
García Rodriguez, et al., 2000, Spain35 943,903/ NR 5 y, 8 mo Adenoma case-patients: adenoma on medical records database with biopsy (n = 1864); CRC case-patients: incident of CRC (n = 2002) Randomly selected age- and sex-matched persons from database; absence of adenoma (n = 10,000) Nonaspirin NSAIDs, aspirin, ibuprofen, diclofenac, naproxen, indomethacin, piroxicam, ketoprofen (prescription database) Good
Morimoto, et al., 2002, U.S.34 1037/1037 3 y Incident adenomatous polyp (n = 474) Persons negative for CRC on colonoscopy (n = 563) Aspirin, nonaspirin NSAIDs (questionnaire) Fair
Logan, et al., 1993, United Kingdom33 476/NR 7 y Patients with positive results on fecal occult blood tests with CRA (n = 147) Patients matched for age and sex; negative controls—patients with negative results on fecal occult blood test; positive controls—patients with positive results on screening found to be free of adenomas and carcinomas on sigmoidoscopy and barium enema (n = 153) Aspirin, NSAIDs, nonaspirin NSAIDs (questionnaire) Fair
Breuer-Katschinski, et al., 2000, Germany36 1265/550 3.5 y Patients with histologically proven and endoscopically removed adenoma of colon or rectum (n = 182) Hospital controls: matched for age and sex, free of adenomatous polyps at colonoscopy (n = 178).

Nonhospital (community) controls: persons of same age and sex as case-patients, selected from inhabitants list of city of Essen (n = 182).
NSAID (questionnaire) Fair
Suh, et al., 1993, U.S.19 2704/NR 9 y Case-patients 1: first primary colon cancer (n = 490)

Case-patients 2: first primary rectal cancer (n = 340)
Controls 1: Healthy persons at preventive health visit (n = 1138)

Controls 2: healthy persons without cancer (n = 524)
Aspirin (questionnaire) Fair
Sandler, et al., 1998, U.S.38 492/379 3 y Patients with incident adenoma (n = 142) Persons free of adenomatous polyps or having hyperplastic polyps (n = 169) Aspirin, NSAID, nonaspirin NSAID (questionnaire) Fair
Kahn, et al., 1998, U.S.37 177,939/ 154,224 10 y Patients with self-reported polyps per mailed questionnaire (n = 7504 men; n = 5111 women) Persons who did not report polyps (n = 65,364 men; n = 76,245 women) Aspirin (questionnaire) Poor

* CRA = colorectal adenoma; CRC = colorectal cancer; CVD = cardiovascular disease; FAP = familial adenomatous polyposis; IBD = inflammatory bowel disease; NHANES = National Health and Nutrition Examination Survey; NHEFS = NHANES I Epidemiologic Follow-up Study; NR = not reported; NSAID = nonsteroidal anti-inflammatory drug; RCT = randomized, controlled trial; U=S= = United States.

Current as of: March 2007

Internet Citation: Evidence Summary: Aspirin: Aspirin/NSAIDs for Prevention of Colorectal Cancer: Preventive Medication. U.S. Preventive Services Task Force. May 2019.
https://www.uspreventiveservicestaskforce.org/Page/Document/evidence-summary-aspirin/aspirin-nsaids-for-prevention-of-colorectal-cancer-preventive-medication

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