Draft Research Plan
Draft Research Plan for Adolescent Idiopathic Scoliosis: Screening
This opportunity for public comment expired on October 28, 2015 at 8:00 PM EST
Note: This is a Draft Research Plan. This draft is distributed solely for the purpose of receiving public input. It has not been disseminated otherwise by the USPSTF. The final Research Plan will be used to guide a systematic review of the evidence by researchers at an Evidence-based Practice Center. The resulting Evidence Review will form the basis of the USPSTF Recommendation Statement on this topic.
Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.
Draft: Proposed Analytic Framework
The figure shows the analytic framework for screening for adolescent idiopathic scoliosis. On the left side, the population represented is asymptomatic children and adolescents ages 10 to 18 years. In the direct pathway, Key Question 1 has an arrow from screening to a) the intermediate outcome of Cobb angle measurement and b) the health outcomes of morbidity, mortality, quality of life, and functioning. In the indirect pathway, Key Question 2 has an arrow from the population to “idiopathic scoliosis,” which represents screening test accuracy. Treatment has a line to a) the intermediate outcome and b) health outcomes (Key Question 3). The harms Key Questions are represented with curved arrows at the bottom of the figure: “harms of screening” (Key Question 5) and “harms of treatment” (Key Question 6).
Draft: Proposed Key Questions to Be Systematically Reviewed
- Does screening for adolescent idiopathic scoliosis improve: a) health outcomes and b) the degree of abnormal spinal curve in childhood or adulthood?
- What is the accuracy of screening for adolescent idiopathic scoliosis?
- Does treatment of adolescent idiopathic scoliosis with a Cobb angle of less than 50° at diagnosis improve: a) health outcomes and b) the degree of spinal curve in childhood or adulthood?
- What is the association between Cobb angle measurement in adolescence and health outcomes in adulthood?
- What are the harms of screening for adolescent idiopathic scoliosis?
- What are the harms of treatment of adolescent idiopathic scoliosis with a Cobb angle of less than 50° at diagnosis?
Draft: Proposed Research Approach
The proposed Research Approach identifies the study characteristics and criteria that the Evidence-based Practice Center will use to search for publications and to determine whether identified studies should be included or excluded from the Evidence Review. Criteria are overarching as well as specific to each of the key questions (KQs).
|Populations||KQs 1, 2, 5: Asymptomatic children and adolescents ages 10 to 18 years
KQs 3, 6: Persons with adolescent idiopathic scoliosis diagnosed at ages 10 to 18 years with a Cobb angle of 10° to 50° detected through screeningKQ 4: Persons with adolescent idiopathic scoliosis diagnosed at ages 10 to 18 years with a Cobb angle of 10° to 50°
|Persons with scoliosis of:
||Specialty care (e.g., surgical clinics and clinics for conditions known to be associated with scoliosis) and other settings with a symptomatic population|
|Screening tests||KQs 1, 2, 5: Forward bend test (with or without scoliometer/inclinometer), surface topography, or other methods (e.g., back-contour device), followed by x-ray for confirmation
KQ 2: Studies with a reference standard
|KQs 1, 2, 5:
|Treatments||KQs 3, 6:
|Comparison||KQs 1, 2, 5: Usual care
KQs 3, 6: Observation, usual care
|KQs 1, 2, 5: Studies with no comparator
KQs 3, 6: Comparative effectiveness studies
|Harms||KQ 5: Any screening harms, including but not limited to: labeling, radiation exposure
KQ 6: Any treatment harms, including but not limited to: psychosocial harms, physiological harms, functioning, or pain
|KQs 5, 6: Studies with no comparator|
|Outcomes||Intermediate outcomes: Cobb angle measurement
|Study design||KQs 1–4: Randomized, controlled trials; controlled trials; cohort studies
KQs 5, 6: Randomized, controlled trials; controlled trials; cohort studies; case series
|All KQs: Studies rated as poor quality
KQs 1–4: Case series, cost-effectiveness studies, qualitative study designs
Internet Citation: Draft Research Plan: Adolescent Idiopathic Scoliosis: Screening. U.S. Preventive Services Task Force. November 2016.