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Clinical Summary

Vitamin D and Calcium to Prevent Fractures: Preventive Medication

Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.

Clinical Summary of U.S. Preventive Services Task Force Recommendation

Population Men or premenopausal women Community-dwelling postmenopausal women at doses of >400 IU of vitamin D3 and >1,000 mg of calcium Community-dwelling postmenopausal women at doses of ≤400 IU of vitamin D3 and ≤1,000 mg of calcium
Recommendation No recommendation. Grade: I statement No recommendation.
Grade: I statement
Do not supplement.
Grade: D recommendation
Preventive Medications Appropriate intake of vitamin D and calcium are essential to overall health. However, there is inadequate evidence to determine the effect of combined vitamin D and calcium supplementation on the incidence of fractures in men or premenopausal women.

There is adequate evidence that daily supplementation with 400 IU of vitamin D3 and 1,000 mg of calcium has no effect on the incidence of fractures in postmenopausal women.

There is inadequate evidence regarding the effect of higher doses of combined vitamin D and calcium supplementation on fracture incidence in community-dwelling postmenopausal women.

Balance of Benefits and Harms Evidence is lacking regarding the benefit of daily vitamin D and calcium supplementation for the primary prevention of fractures, and the balance of benefits and harms cannot be determined. Evidence is lacking regarding the benefit of daily supplementation with >400 IU of vitamin D3 and >1,000 mg of calcium for the primary prevention of fractures in postmenopausal women, and the balance of benefits and harms cannot be determined. Daily supplementation with ≤400 IU of vitamin D3 and ≤1,000 mg of calcium has no net benefit for the primary prevention of fractures.
Other Relevant USPSTF Recommendations These recommendations are available at http://www.uspreventiveservicestaskforce.org.

For a summary of the evidence systematically reviewed in making these recommendations, the full recommendation statement, and supporting documents, please go to http://www.uspreventiveservicestaskforce.org.

Disclaimer: Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.
 

Current as of: February 2013

Internet Citation: Clinical Summary: Vitamin D and Calcium to Prevent Fractures: Preventive Medication. U.S. Preventive Services Task Force. October 2014.
https://www.uspreventiveservicestaskforce.org/Page/Document/ClinicalSummaryFinal/vitamin-d-and-calcium-to-prevent-fractures-preventive-medication

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