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Table 2. Percentage of Reduction in Breast Cancer Mortality Maintained When Moving From an Annual Screening Interval to a Biennial Interval, by Screening Strategy and Model

Modela Maintained Reduction in Breast Cancer Mortality, by Screening Strategy, %b
50-69 y
40-69 y
45-69 y
40-79 y
40-84 y
55-69 y
60-69 y
50-74 y
50-79 y
50-84 y
D 76 75 78 79 82 83 79 81 78 83
E 75 737475757573767576
G 85 869187889186898889
M 90 969797999284959395
S 74 737876778074798579
W 68 677070717170727073

aModel group abbreviations: D = Dana-Farber Cancer Institute; E = Erasmus Medical Center; G = Georgetown University; M = M.D. Anderson Cancer Center; S = Stanford University; W = University of Wisconsin/Harvard.
b Differences in the range of results reflect differences in modeling approaches. For example, the benefit of screening in model M is modeled through stage shift, as with most other models, but also includes a "beyond stage shift" factor based on a cure fraction for small tumors. However, because many of these "cures" occur among women with invasive cancer that is not fatal, finding such cancer 1 year earlier confers very little mortality advantage to annual (vs. biennial) screening.

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