A Decision Analysis for the U.S. Preventive Services Task Force
Prepared by A.G. Zauber, I. Lansdorp-Vogelaar, A.B. Knudsen, J. Wilschut, M.v. Ballegooijen, and K.M. Kuntz.
The information in this report is intended to help clinicians, employers, policymakers, and others make informed decisions about the provision of health care services. This report is intended as a reference and not as a substitute for clinical judgment.
This report may be used, in whole or in part, as the basis for the development of clinical practice guidelines and other quality enhancement tools, or as a basis for reimbursement and coverage policies. AHRQ or U.S. Department of Health and Human Services endorsement of such derivative products may not be stated or implied.
This report was first published in Annals of Internal Medicine 2008;149:659-69.
Background: The U.S. Preventive Services Task Force requested a decision analysis to inform their update of the recommendations for colorectal cancer screening.
Objective: To assess life-years gained and colonoscopy requirements for colorectal cancer screening strategies and identify a set of recommendable screening strategies.
Design: Decision analysis using 2 colorectal cancer microsimulation models from the Cancer Intervention and Surveillance Modeling Network.
Data Sources: Derived from the literature.
Target Population: U.S. average-risk 40-year-old population.
Time Horizon: Lifetime.
Interventions: Fecal occult blood tests (FOBTs), flexible sigmoidoscopy, or colonoscopy screening beginning at age 40, 50, or 60 years and stopping at age 75 or 85 years, with screening intervals of 1, 2, or 3 years for FOBT and 5, 10, or 20 years for sigmoidoscopy and colonoscopy.
Outcome Measures: Number of life-years gained compared with no screening and number of screening tests required.
Results of Base-Case Analysis: Beginning screening at age 50 years was consistently better than at age 60. Decreasing the stop age from 85 to 75 years decreased life-years gained by 1% to 4%, whereas colonoscopy use decreased by 4% to 15%. Assuming equally high adherence, 4 strategies provided similar life-years gained: colonoscopy every 10 years, annual Hemoccult SENSA (Beckman Coulter, Fullerton, California) testing or fecal immunochemical testing, and sigmoidoscopy every 5 years with midinterval Hemoccult SENSA. Hemoccult II and flexible sigmoidoscopy every 5 years alone were less effective.
Results of Sensitivity Analysiss: The results were most sensitive to beginning screening at age 40 years.
Limitations: The stopping age for screening was based only on chronological age.
Conclusions: The findings support colorectal cancer screening with the following: colonoscopy every 10 years, annual screening with a sensitive FOBT, or flexible sigmoidoscopy every 5 years with a midinterval sensitive FOBT from ages 50 to 75 years.
Despite recent declines in both incidence and mortality,1 colorectal cancer remains the second most common cause of cancer death in the United States.2 Screening for colorectal cancer reduces mortality by allowing physicians to detect cancer at earlier, more treatable stages, as well as to identify and remove adenomatous polyps (asymptomatic benign precursor lesions that may lead to colorectal cancer). Many tests are available for screening, such as fecal occult blood tests (FOBTs), flexible sigmoidoscopy, and colonoscopy. Screening with FOBT (Hemoccult II, Beckman Coulter, Fullerton, California) has been shown to reduce colorectal cancer mortality by 15% to 33% in randomized, controlled trials,3-5 and screening with more sensitive FOBTs, flexible sigmoidoscopy, colonoscopy, or combinations of these tests may reduce the burden of colorectal cancer even more.6,7 In the absence of adequate clinical trial data on several recommended screening strategies, microsimulation modeling can provide guidance on the risks, benefits, and testing resources required for different screening strategies to reduce the burden of colorectal cancer.
In July 2002, the U.S. Preventive Services Task Force (USPSTF) concluded that there was sufficient evidence to recommend strongly that all average-risk adults 50 years of age and older should be offered colorectal cancer screening.8 However, the logistics of screening, such as the type of screening test, screening interval, and age at which to stop screening, were not evaluated in terms of the balance of benefits and potential harms. The USPSTF has again addressed recommendations for colorectal cancer screening with a systematic review of the evidence9 on screening tests. For this assessment, the USPSTF requested a decision analysis to project expected outcomes of various strategies for colorectal cancer screening. Two independent microsimulation modeling groups from the Cancer Intervention and Surveillance Modeling Network (CISNET), funded by the National Cancer Institute, used a comparative modeling approach to compare life-years gained relative to resource use of different strategies for colorectal cancer screening.
We used 2 microsimulation models, MISCAN (MIcrosimulation Screening Analysis)10-12 and SimCRC (Simulation Model of Colorectal Cancer),13 to estimate the life-years gained relative to no screening and the colonoscopies required (that is, an indicator for resource use and risk for complications) for different colorectal cancer screening strategies defined by test, age at which to begin screening, age at which to stop screening, and screening interval. We aimed to identify a set of recommendable strategies with similar clinical benefit and an efficient use of colonoscopy resources. Using 2 models (that is, a comparative modeling approach) adds credibility to the results and serves as a sensitivity analysis on the underlying structural assumptions of the models, particularly pertaining to the unobservable natural history of colorectal cancer.
The Appendix describes the MISCAN and SimCRC models, and standardized model profiles are available at http://cisnet.cancer.gov/profiles/. In brief, both models simulate the life histories of a large population of individuals from birth to death. As each individual ages, there is a chance that an adenoma will develop. One or more adenomas can occur in an individual, and each adenoma can independently develop into preclinical (that is, undiagnosed) colorectal cancer (Figure 1). The risk for developing an adenoma depends on age, sex, and baseline individual risk. The models track the location and size of each adenoma; these characteristics influence disease progression and the chance of the adenoma's being found by screening. The size of adenomas can progress from small (≤5 mm) to medium (6 to 9 mm) to large (≥10 mm). Some adenomas eventually become malignant, transforming to stage I preclinical cancer. Preclinical cancer has a chance of progressing through stages I to IV, and may be diagnosed by symptoms at any stage. Survivorship after diagnosis depends on the stage of disease.
The natural history component of each model was calibrated to 1975-1979 clinical incidence data14 and adenoma prevalence from autopsy studies in the same period.15-24 We used this period because incidence rates and adenoma prevalence had not yet been affected by screening. We corrected the adenoma prevalence for studies of non-U.S. populations by using standardized colorectal cancer incidence ratios. The models use all-cause mortality estimates from the U.S. life tables and stage-specific data on colorectal cancer survival from the 1996-1999 Surveillance, Epidemiology, and End Results program.14 Table 1 compares outcomes from the natural history components of the models.
The effectiveness of a screening strategy is modeled through a test's ability to detect lesions (that is, adenomas or preclinical cancer). Once screening is introduced, a simulated person who has an underlying lesion has a chance of having it detected during a screening round depending on the sensitivity of the test for that lesion and whether the lesion is within the reach of the test. Screened persons without an underlying lesion can have a false-positive test result and undergo unnecessary follow-up colonoscopy. Hyperplastic polyps are not modeled explicitly, but their detection is reflected in the specificity of the screening tests. The models incorporate the risk for fatal complications associated with perforation during colonoscopy. Both models have been validated against the long-term reductions in incidence and mortality of colorectal cancer with annual FOBT reported in the Minnesota Colon Cancer Control Study3,25,26 and show good concordance with the trial results.
Strategies for Colorectal Cancer Screening
In consultation with the USPSTF, we included the following basic strategies: 1) no screening, 2) colonoscopy, 3) FOBT (Hemoccult II, Hemoccult SENSA [Beckman Coulter], or fecal immunochemical test), 4) flexible sigmoidoscopy (with biopsy), and 5) flexible sigmoidoscopy combined with Hemoccult SENSA. For each basic strategy, we evaluated start ages of 40, 50, and 60 years and stop ages of 75 and 85 years. For the FOBT strategies, we considered screening intervals of 1, 2, and 3 years, and for the sigmoidoscopy and colonoscopy strategies we considered intervals of 5, 10, and 20 years. These variations resulted in 145 strategies: 90 single-test strategies, 54 combination-test strategies, and 1 no-screening strategy. The stop age reflects the oldest possible age at which to screen, but the actual stopping age is dictated by the start age and screening interval.
In the base case, we assumed 100% adherence for screening tests, follow-up of positive findings, and surveillance of persons found to have adenomas. Individuals with a positive FOBT result or with an adenoma detected by sigmoidoscopy were referred for follow-up colonoscopy. For years in which both tests were due for the combined strategy, the FOBT was performed first; if the result was positive, the patient was referred for follow-up colonoscopy. In those years, flexible sigmoidoscopy was done only for patients with a negative FOBT result. If findings on the follow-up colonoscopy were negative, the individual was assumed to undergo subsequent screening with colonoscopy with a 10-year interval (as long as results of the repeated colonoscopy were negative) and did not return to the initial screening schedule, as is the recommendation of the U.S. Multi-Society Task Force and American Cancer Society.7,27 All individuals with an adenoma detected were followed with colonoscopy surveillance per the Multi-Society guidelines.27,28 The surveillance interval depended on the number and size of the adenomas detected on the last colonoscopy; it ranged from 3 to 5 years and was assumed to continue for the remainder of the person's lifetime.
We estimated the test characteristics of colorectal cancer screening from a review of the available literature (Table 2).29 We conducted this review independently of and parallel in time with the systematic evidence review performed for the USPSTF.9
Evaluation of Outcomes
Determination of Efficient Strategies
The most effective strategy was defined as the one with the greatest life-years gained relative to no screening. However, it is important to consider the relative intensity of test use required to achieve those gains. The more effective strategies tended to be associated with more colonoscopies on average in a person's lifetime, which translated into an increased risk for colonoscopy-related complications. We used an approach that mirrors that of cost-effectiveness analysis30 to identify the set of efficient, or dominant, strategies within each test category. A strategy was considered dominant when no other strategy or combination of strategies provided more life-years with the same number of colonoscopies. We conducted this analysis separately for each of the 5 basic screening strategies because the number of noncolonoscopy tests differed by strategy. We then ranked the efficient screening strategies by increasing effectiveness and calculated the incremental number of colonoscopies (ΔCOL) per 1000, the incremental life-years gained (ΔLYG) per 1000, and the incremental number of colonoscopies necessary to achieve a year of life (ΔCOL/ΔLYG) relative to the next less effective strategy, which we call the "efficiency ratio." The line connecting the set of efficient strategies is called the (efficient) frontier. We also identified "near-efficient" strategies—strategies that yielded life-years gained within 98% of the efficient frontier.
Determination of Recommendable Strategies at a Certain Level of Effectiveness
We further considered only efficient or near-efficient strategies. We assumed that the set of recommendable strategies would have the same start and stop age because recommending different start and stop ages by test may be confusing for patients and practitioners. We looked at the incremental number of colonoscopies relative to the life-years gained to determine what would be reasonable start and stop ages. For a given start and stop age we selected a colonoscopy strategy; the default was the generally recommended 10-year screening interval. From the other test categories we selected strategies with a screening effectiveness most similar to that of colonoscopy, and with a lower efficiency ratio than that for colonoscopy. This was because strategies with more intensive use of tests other than colonoscopy should have a lower efficiency ratio than strategies with less intensive (or no) use of noncolonoscopy tests (that is, this ratio would be higher if other tests were included in the numerator). Alternative sets of recommendable strategies for colorectal cancer screening were obtained with different colonoscopy strategies selected as the initial comparator.
The primary sensitivity analysis was the comparison of findings across the 2 independently developed microsimulation models. We also performed sensitivity analyses on test characteristics in which we used all of the least favorable values in a worst-case analysis and all of the most favorable values in a best-case analysis (Table 2). For colonoscopy and sigmoidoscopy, we used the confidence intervals reported in the meta-analysis by van Rijn31 as the range tested. For FOBT, we used the ranges reported in the literature.9,29
To assess the relative effect of decreased adherence, we explored the impact of overall adherence rates of 50% and 80%. We incorporated correlation of screening behavior within an individual by assuming that the population comprises 4 groups: those who are never screened and those with low, moderate, and high adherence; 10% of the population was in the never-screened group and 30% were in each of the other groups. For both overall screening adherence assumptions (that is, 50% and 80%), we assumed that adherence with follow-up and surveillance was 75%, 85%, and 95% for those with low, moderate, and high adherence, respectively. We assumed that individuals remain in their screening behavior group.
Role of the Funding Source
The National Cancer Institute supported the infrastructure for the CISNET models. The Agency for Healthcare Research and Quality funded this work and provided project oversight and review. The authors worked with 4 USPSTF members to specify the overall questions, select the strategies, and resolve methodologic issues during the conduct of the review. The draft decision analysis was reviewed by 3 external peer reviewers (listed in the acknowledgments) and was revised for the final version. The authors have sole responsibility for the models and model results.
This research did not include patient-specific information and was exempt from institutional review board review.
Table 3 presents the life-years gained, the number of colonoscopies, and the efficiency ratio for each efficient and near-efficient colonoscopy strategy for both models. Similar results for the other tests can be found in the Appendix Table. For illustration, Figure 2 presents the life-years gained relative to the number of colonoscopies and the efficient frontier for all colonoscopy strategies.
Age at Which To Begin Screening
The results from the MISCAN and SimCRC models were consistent in evaluating strategies with age to begin screening of 50 or 60 years, with the start age of 50 predominating among the efficient or near-efficient strategies (Table 3, Appendix). However, the SimCRC model showed favorable results for the strategies in which screening begins at age 40, but these results were not corroborated by the MISCAN model. To illustrate this difference, Figure 2 shows the efficient frontier with age 40 included for colonoscopy ("Frontier 40, 50, 60 y") and without age 40 ("Frontier 50, 60 y"). Similar results were found for the other tests (results not shown). Because the evidence for both adenoma prevalence at age 40 and the duration of the adenoma-carcinoma sequence is weak, we restricted further analysis to start ages of 50 and 60.
Age at Which To Stop Screening
For both models and all tests, decreasing the stopping age from 85 to 75 yielded small reductions in life-years gained relative to large reductions in the number of colonoscopies required (Appendix Table). For example, stopping screening at age 75 instead of 85 for colonoscopy every 10 years would decrease the number of life-years gained with colonoscopy screening by 5 per 1000 individuals for MISCAN and by 2 per 1000 individuals for SimCRC, but would substantially decrease the number of colonoscopies by 398 and 358 per 1000 individuals for MISCAN and SimCRC, respectively (Table 3). This is illustrated by the substantial reduction in the efficiency ratio for these 2 strategies, from 73 to 30 for MISCAN and 179 to 35 for SimCRC.
In general, strategies with longer intervals provided fewer life-years gained than did strategies with shorter intervals. For all single test strategies, the currently recommended intervals of annual FOBT, flexible sigmoidoscopy every 5 years, and colonoscopy every 10 years provided a reasonable ratio of incremental colonoscopies per life-year gained10-35 for ages 50 to 75 (Appendix Table). The results from both models showed that the current recommendation for the combination of flexible sigmoidoscopy every 5 years with a high-sensitivity FOBT annually had a high efficiency ratio, and that moving to a strategy of sigmoidoscopy every 5 years with FOBT every 3 years would minimally decrease the number of life-years gained with combination screening (by 9 per 1000 individuals for MISCAN and by 17 per 1000 individuals for SimCRC) and would substantially decrease the number of colonoscopies (by 765 per 1000 individuals for MISCAN and by 1011 per 1000 individuals for SimCRC for ages 50 to 75) (Appendix Table). This would substantially reduce the incremental colonoscopies required for an additional life-year gained from 155 to 16 for MISCAN and from 154 to 7 for SimCRC.
Identifying a Set of Recommendable Strategies for Colorectal Cancer Screening
In the preceding analysis, we found that a start age of 50 and a stop age of 75 were most reasonable when we considered both benefit and resource use. For those start and stop ages, we first selected the colonoscopy strategy with 10-year intervals because this has been the recommended interval; shortening the interval resulted in a marked increase in efficiency ratio (from 75 to 30 for MISCAN and 179 to 35 for SimCRC) (Table 3). The noncolonoscopy strategies were then chosen to have the same start and stop ages and a lower efficiency ratio, while saving similar life-years as that for colonoscopy (Table 4). The sensitive annual FOBT strategies (Hemoccult SENSA and fecal immunochemical test) were similar to colonoscopy every 10 years in terms of life-years gained. The less sensitive FOBT (Hemoccult II) performed annually did not have effectiveness similar to that of the other FOBTs or to that of colonoscopy. Flexible sigmoidoscopy every 5 years, although showing a reasonable efficiency ratio, did not have effectiveness similar to that of the other strategies. The combination of flexible sigmoidoscopy every 5 years with Hemoccult SENSA every 3 years had a reasonable efficiency ratio (lower than that of colonoscopy and the sensitive FOBTs) and had relatively similar life-years gained. Had we selected the 20-year interval for colonoscopy as the comparator strategy instead of the 10-year interval, the set of strategies would include biennial screening for sensitive FOBT, annual screening for Hemoccult II, and screening with sigmoidoscopy every 10 years in combination with FOBT every 3 years. The life-years gained for this set of screening strategies is approximately 8% to 12% lower than that shown in Table 4.
Our overall conclusions did not change with variations in test characteristics. As expected, results for the worst-case analysis showed fewer life-years gained than results for the base case, and the best-case analysis had more life-years gained. For strategies that remained on the efficient frontier, the incremental number of colonoscopies per life-year gained was typically greater than the base-case value with the best-case assumption, and lower with the worst-case assumption.
Figure 3 shows the expected number of colonoscopies and life-years gained for adherence of 50%, 80%, and 100% for the recommended strategies shown in Table 4. When adherence was relatively high at 80%, the colonoscopy strategy (that is, screening every 10 years from ages 50 to 75) was the most effective in term of life-years gained; Hemoccult SENSA, fecal immunochemical test, and the combination strategies all provided life-years gained within 8% of those of the colonoscopy strategy. When overall adherence was only 50%, the colonoscopy strategy was no longer the most effective, and Hemoccult SENSA, fecal immunochemical test, and the combination strategies had life-years gained greater or equivalent to those of the colonoscopy strategy. Annual Hemoccult II and flexible sigmoidoscopy every 5 years remained the least attractive alternatives in terms of life-years gained across different adherence levels.
We used 2 independent microsimulation models to evaluate different strategies for colorectal cancer screening defined by screening test, age at which to begin screening, interval to repeat screening, and age at which to stop screening. Our goal was to provide the USPSTF with information that synthesizes and translates multiple sources of data, such as screening test characteristics, into projections of clinical benefit and resource utilization for multiple screening options. We found several screening strategies (colonoscopy every 10 years, high-sensitivity FOBT performed annually, and flexible sigmoidoscopy every 5 years with Hemoccult SENSA every 2 to 3 years) that provide similar gains in life-years—if there is equally high adherence for all aspects of the screening process. Our analysis also found that annual FOBT with a lower-sensitivity test (for example, Hemoccult II) and flexible sigmoidoscopy alone resulted in fewer life-years gained relative to other strategies. Our analysis confirmed the current recommendation to begin screening at age 50 in an asymptomatic general population and showed that stopping at age 75 after consecutive negative screenings since age 50 provides almost the same benefit as stopping at age 85, but with substantially fewer colonoscopy resources and risk for complications.
Our decision analysis represents the first time that the USPSTF has included simulation modeling to help inform their decision on recommendations. The USPSTF had previously recommended screening for all asymptomatic persons beginning at age 50 but did not recommend one test over another or an age at which to stop screening.6 Although randomized, controlled trials are the preferred method for establishing effectiveness of (screening) interventions, they are expensive, require long follow-up, and can address only a limited number of comparison groups. However, well-validated microsimulation models may be used to highlight the tradeoff between clinical benefit and resource utilization from different screening policies and inform decision making with standardized comparisons of net benefits and risks. The process with which our analysis was conducted represents an important advancement from evidence-based to evidence-informed medicine, and the use of more than one model, as advocated by CISNET, adds credibility when model results agree.
We found that colorectal cancer screening with high-sensitivity FOBT (Hemoccult SENSA or fecal immunochemical test) provided similar life-years gained as colonoscopy, even though the individual test characteristics were substantially better for colonoscopy (Table 2). This finding was partially due to the fact the FOBT must be performed every year compared with every 10 years for colonoscopy, and the test characteristics are assumed to remain unchanged with each subsequent screening. For example, if an adenoma was missed by a screening test in one cycle, then the chance that it would be missed again on the next examination is still based on the false-negative rate (1- sensitivity for adenomas). There is little evidence on whether test sensitivity varies with increasing rounds of testing. In addition, a substantial percentage of individuals on annual FOBT screening will eventually have a false-positive screening test with referral for colonoscopy. Once confirmed to be negative by colonoscopy, they then have colonoscopy screening every 10 years, as per guidelines. For example, with a specificity of 92.5% for Hemoccult SENSA, the percentage of people in a colonoscopy screening program is about 54% after 10 FOBTs and about 79% after 20 FOBTs.
There has been no recommended stopping age for colorectal cancer screening.7,27 However, our results indicate that continued screening in 75-year-old persons after consecutive negative screenings since age 50 will add little benefit. Individuals with continuous negative findings by age 75 are unlikely to have a missed adenoma at their last screening or to develop an adenoma that progresses to cancer and subsequent cancer death after their last screening. Surveillance colonoscopies for patients with adenomas detected are continued without a stopping age. We note that our analysis used chronologic age rather than comorbidity-adjusted life expectancy and that the decision to stop screening in practice should consider the age and health of the patient. As a guide, life expectancy at age 75 is 10.5 for men and 12.5 years for women, respectively.32
A few findings can be explained by model differences. Both models incorporate assumptions about the adenoma-carcinoma sequence (that is, the development of colorectal cancer from adenomas), for which limited data are available to estimate the time that it takes (on average) for an adenoma to develop into preclinical cancer. For example, in the MISCAN model, the average time from adenoma development to colorectal cancer diagnosis is 10 years among individuals with colorectal cancer diagnosed (that is, dwell time), whereas in the SimCRC model this value is about 22 years. The implications of these differences were more life-years gained with screening in general, and more favorable results for beginning screening at age 40, with the SimCRC model. The former implication had minimal effect on our conclusions because the relative findings were consistent across models. The latter implication resulted in eliminating the start age of 40 from consideration. Another difference between the models is the distribution of adenomas in the colorectal tract (go to the Appendix and Table 1). In the MISCAN model, adenomas are assumed to have the same distribution as colorectal cancers, while the SimCRC model is calibrated to the distribution of adenomas from autopsy studies. As a result, the MISCAN model found strategies involving sigmoidoscopy to be more effective than did the SimCRC model because a larger proportion of adenomas are within the reach of the sigmoidoscope. Despite this difference, both model results found that the strategy of sigmoidoscopy every 5 years was not as effective as annual screening with a sensitive FOBT or with colonoscopy every 10 years.
There are several limitations and caveats to consider. First, we evaluated only colorectal cancer strategies requested by the USPSTF on the basis of their review of the evidence in 2002,8 and we did not include newer screening tests, such as computed tomographic colonography or the DNA stool test.9,27 Second, because we were not asked to provide a cost-effectiveness analysis, we used the number of colonoscopies as a proxy for resource utilization, as well as nonfatal adverse effects from screening. However, this does not capture all resources required per scenario, although we report the numbers of non-colonoscopy tests (that is, FOBT or flexible sigmoidoscopy) required for each strategy. Third, we assumed 100% adherence with screening, follow-up (that is, chance of undergoing diagnostic colonoscopy if a screening test result is positive), and surveillance for all scenarios to provide outcomes associated with the strategies as they were specified. In practice, adherence is much lower than 100% and varies across type of screening test. We conducted a sensitivity analysis that varied overall adherence but not differentially across strategies. We chose to evaluate strategies assuming equivalent adherence because it is uncertain whether adherence will be higher with noninvasive but more frequent testing, or invasive but less frequent testing. Because we considered 3 different adherence scenarios in Figure 3, readers can compare different adherence levels themselves. We emphasize that in practice adherence is critical and that ultimately the best option for a patient is the one that he or she will attend.7,27 In addition, issues pertaining to the implementation of a screening program, including endoscopy capacity,33-35 professional qualification,36,37 insurance coverage, shared decision making, and how to increase adherence with colorectal cancer screening38 are important considerations for implementing recommendations in practice.
In conclusion, our results support colorectal cancer screening with colonoscopy every 10 years, a sensitive FOBT annually, or flexible sigmoidoscopy every 5 years with a midinterval sensitive FOBT from ages 50 to 75 years. Our findings in general support the 2002 USPSTF recommendations for colorectal cancer screening, with a few exceptions. First, while there is currently no recommended stopping age for colorectal cancer screening, we found that continuing screening after age 75 in individuals who have had regular, consistently negative screenings since age 50 provides minimal benefit for the resources required. Second, we found that screening with Hemoccult II annually and flexible sigmoidoscopy alone every 5 years does not provide effectiveness similar to that of screening annually with a sensitive FOBT or every 10 years with colonoscopy. Finally, if a sensitive FOBT is used, the FOBT screening interval can be extended to 3 years when used in combination with flexible sigmoidoscopy every 5 years. These conclusions were corroborated by 2 independent microsimulation models.