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Table 4. Outcomes for the Recommendable Set of Efficient Screening Strategies

Test, Age Begin-Age Stop, Intervala Outcomes per 1000 Persons (COL) Outcomes per 1000 Persons (Non-COLTests) Outcomes per 1000 Persons (LYG) Efficiency Ratiob Incidence Reduction, % Mortality Reduction, %
MISCAN            
COL, 50-75, 10 4136 0 230 29.6 51.9 64.6
Hemoccult SENSA, 50-75, 1 3350 9541 230 30.9 49.7 66.0
FIT, 50-75, 1 2949 11773 227 25.9 47.2 64.6
Hemoccult II, 50-75, 1 1982 16232 194 14.3 37.1 55.3
FSIG, 50-75, 5 1911 4139 203 9.7 46.8 58.5
FSIG + SENSA, 50-75, 5, 3 2870 5822 230 16.3 51.2 65.7
SimCRC            
COL, 50-75, 10 3756 0 271 34.7 80.6 84.4
Hemoccult SENSA, 50-75, 1 2654 9573 259 22.9 73.2 81.2
FIT, 50-75, 1 2295 11830 256 19.7 70.8 80.0
Hemoccult II, 50-75, 1 1456 16239 218 9.6 56.6 69.0
FSIG, 50-75, 5 995 4483 199 8.4 59.0 62.2
FSIG + SENSA, 50-75, 5, 3 1655 11623 257 7.0 72.2 79.3

COL = colonoscopy; FIT = fecal immunochemical test; FSIG = flexible sigmoidoscopy; LYG = life-years gained compared with no screening;
MISCAN = Microsimulation Screening Analysis; SimCRC = Simulation Model of Colorectal Cancer.
a Age and intervals expressed as years.
b Efficiency ratio corresponds with ΔCOL/ΔLYG in the Appendix Table and represents the relative burden per unit of benefit achieved.

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