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Folic Acid to Prevent Neural Tube Defects

This topic is in the process of being updated. Please go to the Update in Progress section to see the latest documents available.

This topic page summarizes the U.S. Preventive Services Task Force (USPSTF) recommendations on folic acid to prevent neural tube defects.

Current Recommendation

Release Date: May 2009

  • The USPSTF recommends that all women planning or capable of pregnancy take a daily supplement containing 0.4 to 0.8 mg (400 to 800 µg) of folic acid.
    Grade: A recommendation.

Supporting Documents

Recommendation Statement (PDF File, 215 KB; PDF Help)
Supporting Article (PDF File, 162 KB; PDF Help)
Evidence Synthesis (PDF File, 315 KB; PDF Help)
Clinical Summary (PDF File, 85 KB; PDF Help)

Update in Progress

In an effort to make the USPSTF recommendations clearer and its processes more transparent, the Task Force is sharing drafts of many of its documents for public comment, including draft Research Plans and draft Recommendation Statements. As a result, the final Recommendation Statement is not yet available.

Supporting Documents

Research Plan

USPSTF members work with researchers from an independent Evidence-based Practice Center (EPC) to create a Research Plan that guides the systematic review of the evidence. The Research Plan consists of an analytic framework, key questions, and a literature search strategy or research approach.

Research Plan Related Items
Draft Research Plan for Public Comment
(July 10–August 6, 2014)

Current as of August 2014

Internet Citation:

Folic Acid to Prevent Neural Tube Defects, Topic Page. U.S. Preventive Services Task Force. http://www.uspreventiveservicestaskforce.org/uspstf/uspsnrfol.htm


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